Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development
Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation.
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Nature Portfolio
2020
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oai:doaj.org-article:26ec0393d8414ff985171a47ea4a17282021-12-02T17:32:27ZTranslational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development10.1038/s41467-020-15412-82041-1723https://doaj.org/article/26ec0393d8414ff985171a47ea4a17282020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15412-8https://doaj.org/toc/2041-1723Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation.Tatiana PopovitchenkoYongkyu ParkNicholas F. PageXiaobing LuoZeljka KrsnikYuan LiuIva SalamonJessica D. StephensonMatthew L. KrausharNicole L. VolkSejal M. PatelH. R. Sagara WijeratneDiana LiKandarp S. SutharAaron WachMiao SunSebastian J. ArnoldWado AkamatsuHideyuki OkanoLuc PaillardHuaye ZhangSteven BuyskeIvica KostovicSilvia De RubeisRonald P. HartMladen-Roko RasinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020) |
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Science Q Tatiana Popovitchenko Yongkyu Park Nicholas F. Page Xiaobing Luo Zeljka Krsnik Yuan Liu Iva Salamon Jessica D. Stephenson Matthew L. Kraushar Nicole L. Volk Sejal M. Patel H. R. Sagara Wijeratne Diana Li Kandarp S. Suthar Aaron Wach Miao Sun Sebastian J. Arnold Wado Akamatsu Hideyuki Okano Luc Paillard Huaye Zhang Steven Buyske Ivica Kostovic Silvia De Rubeis Ronald P. Hart Mladen-Roko Rasin Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| description |
Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation. |
| format |
article |
| author |
Tatiana Popovitchenko Yongkyu Park Nicholas F. Page Xiaobing Luo Zeljka Krsnik Yuan Liu Iva Salamon Jessica D. Stephenson Matthew L. Kraushar Nicole L. Volk Sejal M. Patel H. R. Sagara Wijeratne Diana Li Kandarp S. Suthar Aaron Wach Miao Sun Sebastian J. Arnold Wado Akamatsu Hideyuki Okano Luc Paillard Huaye Zhang Steven Buyske Ivica Kostovic Silvia De Rubeis Ronald P. Hart Mladen-Roko Rasin |
| author_facet |
Tatiana Popovitchenko Yongkyu Park Nicholas F. Page Xiaobing Luo Zeljka Krsnik Yuan Liu Iva Salamon Jessica D. Stephenson Matthew L. Kraushar Nicole L. Volk Sejal M. Patel H. R. Sagara Wijeratne Diana Li Kandarp S. Suthar Aaron Wach Miao Sun Sebastian J. Arnold Wado Akamatsu Hideyuki Okano Luc Paillard Huaye Zhang Steven Buyske Ivica Kostovic Silvia De Rubeis Ronald P. Hart Mladen-Roko Rasin |
| author_sort |
Tatiana Popovitchenko |
| title |
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| title_short |
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| title_full |
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| title_fullStr |
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| title_full_unstemmed |
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development |
| title_sort |
translational derepression of elavl4 isoforms at their alternative 5′ utrs determines neuronal development |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/26ec0393d8414ff985171a47ea4a1728 |
| work_keys_str_mv |
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