The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause

Osteoporosis is a bone disease characterized by decreased quality and strength of bones so that it becomes porous and fracture. Propolis is known to have many pharmacological activity, including an anti-osteoporosis effect. This study aims to determine the effect of propolis administration and the e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juwita Dian Ayu, Almahdy Almahdy, Abdillah Rahmad, Syahputri Fiony
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	osteoporosis propolis impact strength menopause ovariectomy Medicine R
Acceso en línea:	https://doaj.org/article/26efea1188a74715b972f673bbaf69b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26efea1188a74715b972f673bbaf69b0
record_format	dspace
spelling	oai:doaj.org-article:26efea1188a74715b972f673bbaf69b02021-12-05T14:11:06ZThe bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause2300-667610.2478/cipms-2021-0025https://doaj.org/article/26efea1188a74715b972f673bbaf69b02021-09-01T00:00:00Zhttps://doi.org/10.2478/cipms-2021-0025https://doaj.org/toc/2300-6676Osteoporosis is a bone disease characterized by decreased quality and strength of bones so that it becomes porous and fracture. Propolis is known to have many pharmacological activity, including an anti-osteoporosis effect. This study aims to determine the effect of propolis administration and the effects of propolis dosage variation in preventing osteoporosis based on the strength value of femur bone impact in female white rats in the form of an ovariectomy postmenopausal model. The rats were divided into 5 groups: positive control group (subjected to ovariectomy), negative control group (not subjected to ovariectomy, and treatment groups that were subjected to ovariectomy and given propolis at a dose of 180 mg/kg BW, dose 360 mg/kg BW and dose 720 mg/kg BW. Propolis was administered orally for 30 days. Bone impact strength testing was undertaken after 30 days using an impact testing machine. Research data were analyzed via one-way ANOVA and continued with the Duncan’s Multiple Range Test. From the test results, we noted that propolis administration had an effect on the value of bone strength, with the dose of 720 mg/kg BW and 360 mg/kg BW having a significant effect, compared with others. With an increase in dose, propolis can provide an increase in the value of bone strength in rat bones.Juwita Dian AyuAlmahdy AlmahdyAbdillah RahmadSyahputri FionySciendoarticleosteoporosispropolisimpact strengthmenopauseovariectomyMedicineRENCurrent Issues in Pharmacy and Medical Sciences, Vol 34, Iss 3, Pp 119-122 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis propolis impact strength menopause ovariectomy Medicine R
spellingShingle	osteoporosis propolis impact strength menopause ovariectomy Medicine R Juwita Dian Ayu Almahdy Almahdy Abdillah Rahmad Syahputri Fiony The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
description	Osteoporosis is a bone disease characterized by decreased quality and strength of bones so that it becomes porous and fracture. Propolis is known to have many pharmacological activity, including an anti-osteoporosis effect. This study aims to determine the effect of propolis administration and the effects of propolis dosage variation in preventing osteoporosis based on the strength value of femur bone impact in female white rats in the form of an ovariectomy postmenopausal model. The rats were divided into 5 groups: positive control group (subjected to ovariectomy), negative control group (not subjected to ovariectomy, and treatment groups that were subjected to ovariectomy and given propolis at a dose of 180 mg/kg BW, dose 360 mg/kg BW and dose 720 mg/kg BW. Propolis was administered orally for 30 days. Bone impact strength testing was undertaken after 30 days using an impact testing machine. Research data were analyzed via one-way ANOVA and continued with the Duncan’s Multiple Range Test. From the test results, we noted that propolis administration had an effect on the value of bone strength, with the dose of 720 mg/kg BW and 360 mg/kg BW having a significant effect, compared with others. With an increase in dose, propolis can provide an increase in the value of bone strength in rat bones.
format	article
author	Juwita Dian Ayu Almahdy Almahdy Abdillah Rahmad Syahputri Fiony
author_facet	Juwita Dian Ayu Almahdy Almahdy Abdillah Rahmad Syahputri Fiony
author_sort	Juwita Dian Ayu
title	The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
title_short	The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
title_full	The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
title_fullStr	The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
title_full_unstemmed	The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
title_sort	bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/26efea1188a74715b972f673bbaf69b0
work_keys_str_mv	AT juwitadianayu thebonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT almahdyalmahdy thebonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT abdillahrahmad thebonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT syahputrifiony thebonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT juwitadianayu bonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT almahdyalmahdy bonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT abdillahrahmad bonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause AT syahputrifiony bonestrengtheningeffectsofpropolisinovariectomizedfemalewhiteratsasmodelsforpostmenopause
_version_	1718371409570299904

The bone strengthening effects of propolis in ovariectomized female white rats as models for postmenopause

Ejemplares similares