Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.

The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression of Spry4 mRNA in response to NGF, indicating that Spry4 could modulate intracel...

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Main Authors: Fernando C Alsina, Dolores Irala, Paula A Fontanet, Francisco J Hita, Fernanda Ledda, Gustavo Paratcha
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/26f08dc99e1e46218f686c5a1c274ebe
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