Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study

Abstract The influence of peripheral muscle strength on prognosis after extubation and subsequent functional outcomes is not evident. The objectives of this study were to determine (1) whether peripheral muscle strength can be used as a predictor for patients’ prognoses after extubation, and (2) whe...

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Autores principales:	Tsung-Hsien Wang, Chin-Pyng Wu, Li-Ying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26f09b57bec24ef2937ff68d67dcb2f0
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spelling	oai:doaj.org-article:26f09b57bec24ef2937ff68d67dcb2f02021-12-02T15:07:54ZImpact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study10.1038/s41598-021-95647-72045-2322https://doaj.org/article/26f09b57bec24ef2937ff68d67dcb2f02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95647-7https://doaj.org/toc/2045-2322Abstract The influence of peripheral muscle strength on prognosis after extubation and subsequent functional outcomes is not evident. The objectives of this study were to determine (1) whether peripheral muscle strength can be used as a predictor for patients’ prognoses after extubation, and (2) whether the peripheral muscle strength before extubation is correlated with patients’ subsequent ambulation ability and in-hospital mortality. This study was a prospective observational cohort study. A hand-held dynamometer was used for evaluated the muscle strength of the biceps and quadriceps right before extubation. Besides, after the patients had been transferred from the ICU to the general ward, a 2-minute walk test was performed. A total of 52 patients were enrolled in this study, and the rate of extubation failure was 15%. The muscle strength of the quadriceps was significantly correlated with the prognosis after extubation, 48% of the patients were able to ambulate after being transferred to the general ward. The overall mortality rate was 11%, and there was a significant correlation between the biceps muscle strength and in-hospital mortality. Peripheral muscle strength may serve as an important predictor of a patients’ prognoses after extubation. Poor peripheral muscle strength is indicative of not only a higher risk of re-intubation but also higher in-hospital mortality and poorer functional outcomes. Trial registration: ISRCTN16370134. Registered 30 May 2019, prospectively registered. https://www.isrctn.com/ISRCTN16370134 .Tsung-Hsien WangChin-Pyng WuLi-Ying WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsung-Hsien Wang Chin-Pyng Wu Li-Ying Wang Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
description	Abstract The influence of peripheral muscle strength on prognosis after extubation and subsequent functional outcomes is not evident. The objectives of this study were to determine (1) whether peripheral muscle strength can be used as a predictor for patients’ prognoses after extubation, and (2) whether the peripheral muscle strength before extubation is correlated with patients’ subsequent ambulation ability and in-hospital mortality. This study was a prospective observational cohort study. A hand-held dynamometer was used for evaluated the muscle strength of the biceps and quadriceps right before extubation. Besides, after the patients had been transferred from the ICU to the general ward, a 2-minute walk test was performed. A total of 52 patients were enrolled in this study, and the rate of extubation failure was 15%. The muscle strength of the quadriceps was significantly correlated with the prognosis after extubation, 48% of the patients were able to ambulate after being transferred to the general ward. The overall mortality rate was 11%, and there was a significant correlation between the biceps muscle strength and in-hospital mortality. Peripheral muscle strength may serve as an important predictor of a patients’ prognoses after extubation. Poor peripheral muscle strength is indicative of not only a higher risk of re-intubation but also higher in-hospital mortality and poorer functional outcomes. Trial registration: ISRCTN16370134. Registered 30 May 2019, prospectively registered. https://www.isrctn.com/ISRCTN16370134 .
format	article
author	Tsung-Hsien Wang Chin-Pyng Wu Li-Ying Wang
author_facet	Tsung-Hsien Wang Chin-Pyng Wu Li-Ying Wang
author_sort	Tsung-Hsien Wang
title	Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
title_short	Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
title_full	Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
title_fullStr	Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
title_full_unstemmed	Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
title_sort	impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/26f09b57bec24ef2937ff68d67dcb2f0
work_keys_str_mv	AT tsunghsienwang impactofperipheralmusclestrengthonprognosisafterextubationandfunctionaloutcomesincriticallyillpatientsafeasibilitystudy AT chinpyngwu impactofperipheralmusclestrengthonprognosisafterextubationandfunctionaloutcomesincriticallyillpatientsafeasibilitystudy AT liyingwang impactofperipheralmusclestrengthonprognosisafterextubationandfunctionaloutcomesincriticallyillpatientsafeasibilitystudy
_version_	1718388304657776640

Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study

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