Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.

<h4>Background</h4>To date, there is still no consensus regarding the effect of binocular treatment for amblyopia. The purpose of this systematic review and meta-analysis was to summarize the available evidence to determine whether binocular treatment is more effective than patching in c...

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Autores principales:	Matilde Roda, Marco Pellegrini, Natalie Di Geronimo, Aldo Vagge, Michela Fresina, Costantino Schiavi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26f22dba6f20400f8e37aa6548f333e4
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spelling	oai:doaj.org-article:26f22dba6f20400f8e37aa6548f333e42021-12-02T20:17:10ZBinocular treatment for amblyopia: A meta-analysis of randomized clinical trials.1932-620310.1371/journal.pone.0257999https://doaj.org/article/26f22dba6f20400f8e37aa6548f333e42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257999https://doaj.org/toc/1932-6203<h4>Background</h4>To date, there is still no consensus regarding the effect of binocular treatment for amblyopia. The purpose of this systematic review and meta-analysis was to summarize the available evidence to determine whether binocular treatment is more effective than patching in children with amblyopia.<h4>Methods</h4>Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials) were searched for studies that compared binocular treatment and patching in children with amblyopia. The outcome measures were visual acuity and stereopsis. Pooled effects sizes were calculated with a random-effect model. The standardized difference in means (SDM) with 95% confidence intervals (CI) was calculated. Sensitivity analysis and assessment of publication bias were performed.<h4>Results</h4>Five randomized clinical trials were included. No significant difference in visual acuity between patients treated with binocular treatment and patching was observed (SDM = -0.12; 95% CI: -0.45-0.20; P = 0.464). No significant difference in stereopsis between patients treated with binocular treatment and patching was observed (SDM = -0.07; 95% CI: -0.61-0.48; P = 0.809). For both variables, the between-study heterogeneity was high (respectively, I2 = 61% and I2 = 57%).<h4>Conclusions</h4>This meta-analysis found no convincing evidence supporting the efficacy of binocular treatment as an alternative to conventional patching. Therefore, the binocular treatment cannot fully replace traditional treatment but, to date, it can be considered a valid complementary therapy in peculiar cases. Further studies are required to determine whether more engaging therapies and new treatment protocols are more effective.Matilde RodaMarco PellegriniNatalie Di GeronimoAldo VaggeMichela FresinaCostantino SchiaviPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257999 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matilde Roda Marco Pellegrini Natalie Di Geronimo Aldo Vagge Michela Fresina Costantino Schiavi Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
description	<h4>Background</h4>To date, there is still no consensus regarding the effect of binocular treatment for amblyopia. The purpose of this systematic review and meta-analysis was to summarize the available evidence to determine whether binocular treatment is more effective than patching in children with amblyopia.<h4>Methods</h4>Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials) were searched for studies that compared binocular treatment and patching in children with amblyopia. The outcome measures were visual acuity and stereopsis. Pooled effects sizes were calculated with a random-effect model. The standardized difference in means (SDM) with 95% confidence intervals (CI) was calculated. Sensitivity analysis and assessment of publication bias were performed.<h4>Results</h4>Five randomized clinical trials were included. No significant difference in visual acuity between patients treated with binocular treatment and patching was observed (SDM = -0.12; 95% CI: -0.45-0.20; P = 0.464). No significant difference in stereopsis between patients treated with binocular treatment and patching was observed (SDM = -0.07; 95% CI: -0.61-0.48; P = 0.809). For both variables, the between-study heterogeneity was high (respectively, I2 = 61% and I2 = 57%).<h4>Conclusions</h4>This meta-analysis found no convincing evidence supporting the efficacy of binocular treatment as an alternative to conventional patching. Therefore, the binocular treatment cannot fully replace traditional treatment but, to date, it can be considered a valid complementary therapy in peculiar cases. Further studies are required to determine whether more engaging therapies and new treatment protocols are more effective.
format	article
author	Matilde Roda Marco Pellegrini Natalie Di Geronimo Aldo Vagge Michela Fresina Costantino Schiavi
author_facet	Matilde Roda Marco Pellegrini Natalie Di Geronimo Aldo Vagge Michela Fresina Costantino Schiavi
author_sort	Matilde Roda
title	Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
title_short	Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
title_full	Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
title_fullStr	Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
title_full_unstemmed	Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.
title_sort	binocular treatment for amblyopia: a meta-analysis of randomized clinical trials.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/26f22dba6f20400f8e37aa6548f333e4
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Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials.

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