Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer

Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer

Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.

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Auteurs principaux: Nalinikanth Kotagiri, Matthew L. Cooper, Michael Rettig, Christopher Egbulefu, Julie Prior, Grace Cui, Partha Karmakar, Mingzhou Zhou, Xiaoxia Yang, Gail Sudlow, Lynne Marsala, Chantiya Chanswangphuwana, Lan Lu, LeMoyne Habimana-Griffin, Monica Shokeen, Xinming Xu, Katherine Weilbaecher, Michael Tomasson, Gregory Lanza, John F. DiPersio, Samuel Achilefu
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
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Accès en ligne:https://doaj.org/article/26f55b0e68cc493ba96ad8ac0b602bc1
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Résumé:Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.

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