Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer

Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.

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Autores principales:	Nalinikanth Kotagiri, Matthew L. Cooper, Michael Rettig, Christopher Egbulefu, Julie Prior, Grace Cui, Partha Karmakar, Mingzhou Zhou, Xiaoxia Yang, Gail Sudlow, Lynne Marsala, Chantiya Chanswangphuwana, Lan Lu, LeMoyne Habimana-Griffin, Monica Shokeen, Xinming Xu, Katherine Weilbaecher, Michael Tomasson, Gregory Lanza, John F. DiPersio, Samuel Achilefu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26f55b0e68cc493ba96ad8ac0b602bc1
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spelling	oai:doaj.org-article:26f55b0e68cc493ba96ad8ac0b602bc12021-12-02T15:34:38ZRadionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer10.1038/s41467-017-02758-92041-1723https://doaj.org/article/26f55b0e68cc493ba96ad8ac0b602bc12018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02758-9https://doaj.org/toc/2041-1723Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.Nalinikanth KotagiriMatthew L. CooperMichael RettigChristopher EgbulefuJulie PriorGrace CuiPartha KarmakarMingzhou ZhouXiaoxia YangGail SudlowLynne MarsalaChantiya ChanswangphuwanaLan LuLeMoyne Habimana-GriffinMonica ShokeenXinming XuKatherine WeilbaecherMichael TomassonGregory LanzaJohn F. DiPersioSamuel AchilefuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nalinikanth Kotagiri Matthew L. Cooper Michael Rettig Christopher Egbulefu Julie Prior Grace Cui Partha Karmakar Mingzhou Zhou Xiaoxia Yang Gail Sudlow Lynne Marsala Chantiya Chanswangphuwana Lan Lu LeMoyne Habimana-Griffin Monica Shokeen Xinming Xu Katherine Weilbaecher Michael Tomasson Gregory Lanza John F. DiPersio Samuel Achilefu Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
description	Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.
format	article
author	Nalinikanth Kotagiri Matthew L. Cooper Michael Rettig Christopher Egbulefu Julie Prior Grace Cui Partha Karmakar Mingzhou Zhou Xiaoxia Yang Gail Sudlow Lynne Marsala Chantiya Chanswangphuwana Lan Lu LeMoyne Habimana-Griffin Monica Shokeen Xinming Xu Katherine Weilbaecher Michael Tomasson Gregory Lanza John F. DiPersio Samuel Achilefu
author_facet	Nalinikanth Kotagiri Matthew L. Cooper Michael Rettig Christopher Egbulefu Julie Prior Grace Cui Partha Karmakar Mingzhou Zhou Xiaoxia Yang Gail Sudlow Lynne Marsala Chantiya Chanswangphuwana Lan Lu LeMoyne Habimana-Griffin Monica Shokeen Xinming Xu Katherine Weilbaecher Michael Tomasson Gregory Lanza John F. DiPersio Samuel Achilefu
author_sort	Nalinikanth Kotagiri
title	Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
title_short	Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
title_full	Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
title_fullStr	Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
title_full_unstemmed	Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
title_sort	radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26f55b0e68cc493ba96ad8ac0b602bc1
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Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer

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