Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives

Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study a...

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Autores principales:	Piotr Buda, Joanna Friedman-Gruszczyńska, Janusz Książyk
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Kawasaki disease vasculitis guidelines anti-inflammatory treatment coronary artery aneurysm SARS-CoV-2 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/26f86c469de64241adda0370a9615b51
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spelling	oai:doaj.org-article:26f86c469de64241adda0370a9615b512021-12-01T16:31:51ZAnti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives2296-858X10.3389/fmed.2021.738850https://doaj.org/article/26f86c469de64241adda0370a9615b512021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.738850/fullhttps://doaj.org/toc/2296-858XKawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD.Piotr BudaJoanna Friedman-GruszczyńskaJanusz KsiążykFrontiers Media S.A.articleKawasaki diseasevasculitisguidelinesanti-inflammatory treatmentcoronary artery aneurysmSARS-CoV-2Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kawasaki disease vasculitis guidelines anti-inflammatory treatment coronary artery aneurysm SARS-CoV-2 Medicine (General) R5-920
spellingShingle	Kawasaki disease vasculitis guidelines anti-inflammatory treatment coronary artery aneurysm SARS-CoV-2 Medicine (General) R5-920 Piotr Buda Joanna Friedman-Gruszczyńska Janusz Książyk Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
description	Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD.
format	article
author	Piotr Buda Joanna Friedman-Gruszczyńska Janusz Książyk
author_facet	Piotr Buda Joanna Friedman-Gruszczyńska Janusz Książyk
author_sort	Piotr Buda
title	Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_short	Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_full	Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_fullStr	Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_full_unstemmed	Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_sort	anti-inflammatory treatment of kawasaki disease: comparison of current guidelines and perspectives
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/26f86c469de64241adda0370a9615b51
work_keys_str_mv	AT piotrbuda antiinflammatorytreatmentofkawasakidiseasecomparisonofcurrentguidelinesandperspectives AT joannafriedmangruszczynska antiinflammatorytreatmentofkawasakidiseasecomparisonofcurrentguidelinesandperspectives AT januszksiazyk antiinflammatorytreatmentofkawasakidiseasecomparisonofcurrentguidelinesandperspectives
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Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives

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