Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol

The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes...

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Autor principal: Karli Montague-Cardoso
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/26fb03a1522c4f559b08f2a7931ec656
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spelling oai:doaj.org-article:26fb03a1522c4f559b08f2a7931ec6562021-12-02T17:26:55ZBeta-amyloid production in neurons is regulated by astrocyte-derived cholesterol10.1038/s42003-021-02644-72399-3642https://doaj.org/article/26fb03a1522c4f559b08f2a7931ec6562021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02644-7https://doaj.org/toc/2399-3642The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes. This finding paves the way for future work that will establish whether the selective removal of Aβ by targeting this mechanism has therapeutic potential.Karli Montague-CardosoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Karli Montague-Cardoso
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
description The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes. This finding paves the way for future work that will establish whether the selective removal of Aβ by targeting this mechanism has therapeutic potential.
format article
author Karli Montague-Cardoso
author_facet Karli Montague-Cardoso
author_sort Karli Montague-Cardoso
title Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
title_short Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
title_full Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
title_fullStr Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
title_full_unstemmed Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
title_sort beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/26fb03a1522c4f559b08f2a7931ec656
work_keys_str_mv AT karlimontaguecardoso betaamyloidproductioninneuronsisregulatedbyastrocytederivedcholesterol
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