Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.

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Autores principales:	Yue Li, Michael E. Stockton, Brian E. Eisinger, Yinghua Zhao, Jessica L. Miller, Ismat Bhuiyan, Yu Gao, Zhiping Wu, Junmin Peng, Xinyu Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26fc57d7c2ad436ca758e946a648f712
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spelling	oai:doaj.org-article:26fc57d7c2ad436ca758e946a648f7122021-12-02T17:32:01ZReducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome10.1038/s41467-018-04869-32041-1723https://doaj.org/article/26fc57d7c2ad436ca758e946a648f7122018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04869-3https://doaj.org/toc/2041-1723Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.Yue LiMichael E. StocktonBrian E. EisingerYinghua ZhaoJessica L. MillerIsmat BhuiyanYu GaoZhiping WuJunmin PengXinyu ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Li Michael E. Stockton Brian E. Eisinger Yinghua Zhao Jessica L. Miller Ismat Bhuiyan Yu Gao Zhiping Wu Junmin Peng Xinyu Zhao Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
description	Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.
format	article
author	Yue Li Michael E. Stockton Brian E. Eisinger Yinghua Zhao Jessica L. Miller Ismat Bhuiyan Yu Gao Zhiping Wu Junmin Peng Xinyu Zhao
author_facet	Yue Li Michael E. Stockton Brian E. Eisinger Yinghua Zhao Jessica L. Miller Ismat Bhuiyan Yu Gao Zhiping Wu Junmin Peng Xinyu Zhao
author_sort	Yue Li
title	Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
title_short	Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
title_full	Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
title_fullStr	Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
title_full_unstemmed	Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
title_sort	reducing histone acetylation rescues cognitive deficits in a mouse model of fragile x syndrome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26fc57d7c2ad436ca758e946a648f712
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Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

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