Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.
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Autores principales: | Yue Li, Michael E. Stockton, Brian E. Eisinger, Yinghua Zhao, Jessica L. Miller, Ismat Bhuiyan, Yu Gao, Zhiping Wu, Junmin Peng, Xinyu Zhao |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/26fc57d7c2ad436ca758e946a648f712 |
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