Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery

Rong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to th...

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Autores principales:	Liu R, Lai YS, He B, Li Y, Wang G, Chang S, Gu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/26fdd870ba9d4eafad73950e86722b7f
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spelling	oai:doaj.org-article:26fdd870ba9d4eafad73950e86722b7f2021-12-02T05:09:41ZSupramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery1176-91141178-2013https://doaj.org/article/26fdd870ba9d4eafad73950e86722b7f2012-10-01T00:00:00Zhttp://www.dovepress.com/supramolecular-nanoparticles-generated-by-the-self-assembly-of-polyrot-a11195https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to this paperAbstract: A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in a-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 &micro;g/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.Keywords: polyrotaxane, self-assembly, nanoparticle, doxorubicin, supermolecularLiu RLai YSHe BLi YWang GChang SGu ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5249-5258 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liu R Lai YS He B Li Y Wang G Chang S Gu Z Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
description	Rong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to this paperAbstract: A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in a-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 &micro;g/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.Keywords: polyrotaxane, self-assembly, nanoparticle, doxorubicin, supermolecular
format	article
author	Liu R Lai YS He B Li Y Wang G Chang S Gu Z
author_facet	Liu R Lai YS He B Li Y Wang G Chang S Gu Z
author_sort	Liu R
title	Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
title_short	Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
title_full	Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
title_fullStr	Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
title_full_unstemmed	Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
title_sort	supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/26fdd870ba9d4eafad73950e86722b7f
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Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery

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