Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism

Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.

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Autores principales:	Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato, Yoshiki Kawabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26ff462ed34f4f31ab3d012ea2e86ed2
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spelling	oai:doaj.org-article:26ff462ed34f4f31ab3d012ea2e86ed22021-12-02T16:57:03ZIdentification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism10.1038/ncomms133842041-1723https://doaj.org/article/26ff462ed34f4f31ab3d012ea2e86ed22016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13384https://doaj.org/toc/2041-1723Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.Tatsuya TamuraHiroshi NodaEri JoyashikiMaiko HoshinoTomoyuki WatanabeMasahiko KinosakiYoshikazu NishimuraTohru EsakiKotaro OgawaTaiji MiyakeShinichi AraiMasaru ShimizuHidetomo KitamuraHaruhiko SatoYoshiki KawabeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatsuya Tamura Hiroshi Noda Eri Joyashiki Maiko Hoshino Tomoyuki Watanabe Masahiko Kinosaki Yoshikazu Nishimura Tohru Esaki Kotaro Ogawa Taiji Miyake Shinichi Arai Masaru Shimizu Hidetomo Kitamura Haruhiko Sato Yoshiki Kawabe Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
description	Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.
format	article
author	Tatsuya Tamura Hiroshi Noda Eri Joyashiki Maiko Hoshino Tomoyuki Watanabe Masahiko Kinosaki Yoshikazu Nishimura Tohru Esaki Kotaro Ogawa Taiji Miyake Shinichi Arai Masaru Shimizu Hidetomo Kitamura Haruhiko Sato Yoshiki Kawabe
author_facet	Tatsuya Tamura Hiroshi Noda Eri Joyashiki Maiko Hoshino Tomoyuki Watanabe Masahiko Kinosaki Yoshikazu Nishimura Tohru Esaki Kotaro Ogawa Taiji Miyake Shinichi Arai Masaru Shimizu Hidetomo Kitamura Haruhiko Sato Yoshiki Kawabe
author_sort	Tatsuya Tamura
title	Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
title_short	Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
title_full	Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
title_fullStr	Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
title_full_unstemmed	Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
title_sort	identification of an orally active small-molecule pthr1 agonist for the treatment of hypoparathyroidism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/26ff462ed34f4f31ab3d012ea2e86ed2
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Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism

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