Rasagiline in treatment of Parkinson’s disease
Lakshmi Nayak1, Claire Henchcliffe21Department of Neurology; 2Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USAAbstract: Rasagiline (N-propargyl-1 (R)-aminoindan) is a novel propargylamine, irreversible, selective monoamine oxidase inhibitor for tre...
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Dove Medical Press
2008
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oai:doaj.org-article:2700160b77974365b071192318f7b89c2021-12-02T04:24:59ZRasagiline in treatment of Parkinson’s disease1176-63281178-2021https://doaj.org/article/2700160b77974365b071192318f7b89c2008-03-01T00:00:00Zhttp://www.dovepress.com/rasagiline-in-treatment-of-parkinsonrsquos-disease-a991https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Lakshmi Nayak1, Claire Henchcliffe21Department of Neurology; 2Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USAAbstract: Rasagiline (N-propargyl-1 (R)-aminoindan) is a novel propargylamine, irreversible, selective monoamine oxidase inhibitor for treatment of Parkinson’s disease (PD), a progressive condition associated with degeneration of dopaminergic neurons in the substantia nigra. Rasagiline inhibits striatal dopamine metabolism, thereby providing relief from motor symptoms of PD. It may be dosed once daily and, unlike selegiline, it is metabolized to non-amphetamine compounds. In a large clinical trial, rasagiline has proved effective, safe, and well tolerated in early PD as monotherapy. In two phase III clinical trials in advanced PD with motor fluctuations, rasagiline as an adjunct to levodopa significantly decreases “off” time. In animal models of PD, data supports a neuroprotective effect of rasagiline, and its active metabolite aminoindan. Analysis of delayed-start clinical trial suggests the potential for disease modification, and further trials are examining this effect.Keywords: rasagiline, monoamine oxidase inhibitor, propargylamine, Parkinson’s disease Lakshmi NayakClaire HenchcliffeDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 11-20 (2008) |
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DOAJ |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lakshmi Nayak Claire Henchcliffe Rasagiline in treatment of Parkinson’s disease |
| description |
Lakshmi Nayak1, Claire Henchcliffe21Department of Neurology; 2Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USAAbstract: Rasagiline (N-propargyl-1 (R)-aminoindan) is a novel propargylamine, irreversible, selective monoamine oxidase inhibitor for treatment of Parkinson’s disease (PD), a progressive condition associated with degeneration of dopaminergic neurons in the substantia nigra. Rasagiline inhibits striatal dopamine metabolism, thereby providing relief from motor symptoms of PD. It may be dosed once daily and, unlike selegiline, it is metabolized to non-amphetamine compounds. In a large clinical trial, rasagiline has proved effective, safe, and well tolerated in early PD as monotherapy. In two phase III clinical trials in advanced PD with motor fluctuations, rasagiline as an adjunct to levodopa significantly decreases “off” time. In animal models of PD, data supports a neuroprotective effect of rasagiline, and its active metabolite aminoindan. Analysis of delayed-start clinical trial suggests the potential for disease modification, and further trials are examining this effect.Keywords: rasagiline, monoamine oxidase inhibitor, propargylamine, Parkinson’s disease |
| format |
article |
| author |
Lakshmi Nayak Claire Henchcliffe |
| author_facet |
Lakshmi Nayak Claire Henchcliffe |
| author_sort |
Lakshmi Nayak |
| title |
Rasagiline in treatment of Parkinson’s disease |
| title_short |
Rasagiline in treatment of Parkinson’s disease |
| title_full |
Rasagiline in treatment of Parkinson’s disease |
| title_fullStr |
Rasagiline in treatment of Parkinson’s disease |
| title_full_unstemmed |
Rasagiline in treatment of Parkinson’s disease |
| title_sort |
rasagiline in treatment of parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/2700160b77974365b071192318f7b89c |
| work_keys_str_mv |
AT lakshminayak rasagilineintreatmentofparkinsonamprsquosdisease AT clairehenchcliffe rasagilineintreatmentofparkinsonamprsquosdisease |
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1718401234959859712 |