Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Lipid-like nanoparticles have applications as non-viral delivery systems for mRNA. Here, the authors develop biodegradable lipids with improved clearance and reduced toxicity.

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Autores principales:	Lei Miao, Jiaqi Lin, Yuxuan Huang, Linxian Li, Derfogail Delcassian, Yifan Ge, Yunhua Shi, Daniel G. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27030fbe450d4d599833b622ebae74de
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spelling	oai:doaj.org-article:27030fbe450d4d599833b622ebae74de2021-12-02T17:15:59ZSynergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver10.1038/s41467-020-16248-y2041-1723https://doaj.org/article/27030fbe450d4d599833b622ebae74de2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16248-yhttps://doaj.org/toc/2041-1723Lipid-like nanoparticles have applications as non-viral delivery systems for mRNA. Here, the authors develop biodegradable lipids with improved clearance and reduced toxicity.Lei MiaoJiaqi LinYuxuan HuangLinxian LiDerfogail DelcassianYifan GeYunhua ShiDaniel G. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Miao Jiaqi Lin Yuxuan Huang Linxian Li Derfogail Delcassian Yifan Ge Yunhua Shi Daniel G. Anderson Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
description	Lipid-like nanoparticles have applications as non-viral delivery systems for mRNA. Here, the authors develop biodegradable lipids with improved clearance and reduced toxicity.
format	article
author	Lei Miao Jiaqi Lin Yuxuan Huang Linxian Li Derfogail Delcassian Yifan Ge Yunhua Shi Daniel G. Anderson
author_facet	Lei Miao Jiaqi Lin Yuxuan Huang Linxian Li Derfogail Delcassian Yifan Ge Yunhua Shi Daniel G. Anderson
author_sort	Lei Miao
title	Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
title_short	Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
title_full	Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
title_fullStr	Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
title_full_unstemmed	Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
title_sort	synergistic lipid compositions for albumin receptor mediated delivery of mrna to the liver
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/27030fbe450d4d599833b622ebae74de
work_keys_str_mv	AT leimiao synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT jiaqilin synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT yuxuanhuang synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT linxianli synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT derfogaildelcassian synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT yifange synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT yunhuashi synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver AT danielganderson synergisticlipidcompositionsforalbuminreceptormediateddeliveryofmrnatotheliver
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Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

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