Microfluidic Systems for Cancer Diagnosis and Applications

Microfluidic devices have led to novel biological advances through the improvement of micro systems that can mimic and measure. Microsystems easily handle sub-microliter volumes, obviously with guidance presumably through laminated fluid flows. Microfluidic systems have production methods that do no...

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Autores principales:	Semra Akgönüllü, Monireh Bakhshpour, Ayşe Kevser Pişkin, Adil Denizli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomaterials microfluidics single cell analysis cancer diagnosis Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/2709a12e090f446fafd008b2bb321805
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spelling	oai:doaj.org-article:2709a12e090f446fafd008b2bb3218052021-11-25T18:23:19ZMicrofluidic Systems for Cancer Diagnosis and Applications10.3390/mi121113492072-666Xhttps://doaj.org/article/2709a12e090f446fafd008b2bb3218052021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1349https://doaj.org/toc/2072-666XMicrofluidic devices have led to novel biological advances through the improvement of micro systems that can mimic and measure. Microsystems easily handle sub-microliter volumes, obviously with guidance presumably through laminated fluid flows. Microfluidic systems have production methods that do not need expert engineering, away from a centralized laboratory, and can implement basic and point of care analysis, and this has attracted attention to their widespread dissemination and adaptation to specific biological issues. The general use of microfluidic tools in clinical settings can be seen in pregnancy tests and diabetic control, but recently microfluidic platforms have become a key novel technology for cancer diagnostics. Cancer is a heterogeneous group of diseases that needs a multimodal paradigm to diagnose, manage, and treat. Using advanced technologies can enable this, providing better diagnosis and treatment for cancer patients. Microfluidic tools have evolved as a promising tool in the field of cancer such as detection of a single cancer cell, liquid biopsy, drug screening modeling angiogenesis, and metastasis detection. This review summarizes the need for the low-abundant blood and serum cancer diagnosis with microfluidic tools and the progress that has been followed to develop integrated microfluidic platforms for this application in the last few years.Semra AkgönüllüMonireh BakhshpourAyşe Kevser PişkinAdil DenizliMDPI AGarticlebiomaterialsmicrofluidicssingle cell analysiscancer diagnosisMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1349, p 1349 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials microfluidics single cell analysis cancer diagnosis Mechanical engineering and machinery TJ1-1570
spellingShingle	biomaterials microfluidics single cell analysis cancer diagnosis Mechanical engineering and machinery TJ1-1570 Semra Akgönüllü Monireh Bakhshpour Ayşe Kevser Pişkin Adil Denizli Microfluidic Systems for Cancer Diagnosis and Applications
description	Microfluidic devices have led to novel biological advances through the improvement of micro systems that can mimic and measure. Microsystems easily handle sub-microliter volumes, obviously with guidance presumably through laminated fluid flows. Microfluidic systems have production methods that do not need expert engineering, away from a centralized laboratory, and can implement basic and point of care analysis, and this has attracted attention to their widespread dissemination and adaptation to specific biological issues. The general use of microfluidic tools in clinical settings can be seen in pregnancy tests and diabetic control, but recently microfluidic platforms have become a key novel technology for cancer diagnostics. Cancer is a heterogeneous group of diseases that needs a multimodal paradigm to diagnose, manage, and treat. Using advanced technologies can enable this, providing better diagnosis and treatment for cancer patients. Microfluidic tools have evolved as a promising tool in the field of cancer such as detection of a single cancer cell, liquid biopsy, drug screening modeling angiogenesis, and metastasis detection. This review summarizes the need for the low-abundant blood and serum cancer diagnosis with microfluidic tools and the progress that has been followed to develop integrated microfluidic platforms for this application in the last few years.
format	article
author	Semra Akgönüllü Monireh Bakhshpour Ayşe Kevser Pişkin Adil Denizli
author_facet	Semra Akgönüllü Monireh Bakhshpour Ayşe Kevser Pişkin Adil Denizli
author_sort	Semra Akgönüllü
title	Microfluidic Systems for Cancer Diagnosis and Applications
title_short	Microfluidic Systems for Cancer Diagnosis and Applications
title_full	Microfluidic Systems for Cancer Diagnosis and Applications
title_fullStr	Microfluidic Systems for Cancer Diagnosis and Applications
title_full_unstemmed	Microfluidic Systems for Cancer Diagnosis and Applications
title_sort	microfluidic systems for cancer diagnosis and applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2709a12e090f446fafd008b2bb321805
work_keys_str_mv	AT semraakgonullu microfluidicsystemsforcancerdiagnosisandapplications AT monirehbakhshpour microfluidicsystemsforcancerdiagnosisandapplications AT aysekevserpiskin microfluidicsystemsforcancerdiagnosisandapplications AT adildenizli microfluidicsystemsforcancerdiagnosisandapplications
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Microfluidic Systems for Cancer Diagnosis and Applications

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