Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations

Abstract This study evaluated the association of contact point locations with the knee medial and lateral contact force (Fmed, Flat) alterations in OA and healthy subjects. A musculoskeletal model of the lower limb with subject-specific tibiofemoral contact point trajectories was used to estimate th...

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Autores principales:	Ali Zeighami, Raphael Dumas, Rachid Aissaoui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2709a9d52c9c4c71b273a6ad8f3ddbcb
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spelling	oai:doaj.org-article:2709a9d52c9c4c71b273a6ad8f3ddbcb2021-12-02T18:27:47ZKnee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations10.1038/s41598-021-87978-22045-2322https://doaj.org/article/2709a9d52c9c4c71b273a6ad8f3ddbcb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87978-2https://doaj.org/toc/2045-2322Abstract This study evaluated the association of contact point locations with the knee medial and lateral contact force (Fmed, Flat) alterations in OA and healthy subjects. A musculoskeletal model of the lower limb with subject-specific tibiofemoral contact point trajectories was used to estimate the Fmed and Flat in ten healthy and twelve OA subjects during treadmill gait. Regression analyses were performed to evaluate the correlation of the contact point locations, knee adduction moment (KAM), knee flexion moment (KFM), frontal plane alignment, and gait speed with the Fmed and Flat. Medial contact point locations in the medial–lateral direction showed a poor correlation with the Fmed in OA (R2 = 0.13, p = 0.01) and healthy (R2 = 0.24, p = 0.001) subjects. Anterior–posterior location of the contact points also showed a poor correlation with the Fmed of OA subjects (R2 = 0.32, p < 0.001). Across all subjects, KAM and KFM remained the best predictors of the Fmed and Flat, respectively (R2 between 0.62 and 0.69). Results suggest different mechanisms of contact force distribution in OA joints. The variations in the location of the contact points participate partially to explains the Fmed variations in OA subjects together with the KFM and KAM.Ali ZeighamiRaphael DumasRachid AissaouiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Zeighami Raphael Dumas Rachid Aissaoui Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
description	Abstract This study evaluated the association of contact point locations with the knee medial and lateral contact force (Fmed, Flat) alterations in OA and healthy subjects. A musculoskeletal model of the lower limb with subject-specific tibiofemoral contact point trajectories was used to estimate the Fmed and Flat in ten healthy and twelve OA subjects during treadmill gait. Regression analyses were performed to evaluate the correlation of the contact point locations, knee adduction moment (KAM), knee flexion moment (KFM), frontal plane alignment, and gait speed with the Fmed and Flat. Medial contact point locations in the medial–lateral direction showed a poor correlation with the Fmed in OA (R2 = 0.13, p = 0.01) and healthy (R2 = 0.24, p = 0.001) subjects. Anterior–posterior location of the contact points also showed a poor correlation with the Fmed of OA subjects (R2 = 0.32, p < 0.001). Across all subjects, KAM and KFM remained the best predictors of the Fmed and Flat, respectively (R2 between 0.62 and 0.69). Results suggest different mechanisms of contact force distribution in OA joints. The variations in the location of the contact points participate partially to explains the Fmed variations in OA subjects together with the KFM and KAM.
format	article
author	Ali Zeighami Raphael Dumas Rachid Aissaoui
author_facet	Ali Zeighami Raphael Dumas Rachid Aissaoui
author_sort	Ali Zeighami
title	Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
title_short	Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
title_full	Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
title_fullStr	Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
title_full_unstemmed	Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations
title_sort	knee loading in oa subjects is correlated to flexion and adduction moments and to contact point locations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2709a9d52c9c4c71b273a6ad8f3ddbcb
work_keys_str_mv	AT alizeighami kneeloadinginoasubjectsiscorrelatedtoflexionandadductionmomentsandtocontactpointlocations AT raphaeldumas kneeloadinginoasubjectsiscorrelatedtoflexionandadductionmomentsandtocontactpointlocations AT rachidaissaoui kneeloadinginoasubjectsiscorrelatedtoflexionandadductionmomentsandtocontactpointlocations
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Knee loading in OA subjects is correlated to flexion and adduction moments and to contact point locations

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