Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder

Abstract Hyperactivity of limbic (e.g., amygdalar) responses to negative stimuli has been implicated in the pathophysiology of generalized anxiety disorder (GAD). Evidence has also suggested that even a simple cognitive task involving emotionally salient stimuli can modulate limbic and prefrontal ne...

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Autores principales:	Dazhi Yin, Wenjing Liu, Kristina Zeljic, Qian Lv, Zhiwei Wang, Meina You, Weiwei Men, Mingxia Fan, Wenhong Cheng, Zheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/270ad6d7b0264f1bb07b2c6df1484302
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spelling	oai:doaj.org-article:270ad6d7b0264f1bb07b2c6df14843022021-12-02T12:32:20ZFailure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder10.1038/s41598-017-07063-52045-2322https://doaj.org/article/270ad6d7b0264f1bb07b2c6df14843022017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07063-5https://doaj.org/toc/2045-2322Abstract Hyperactivity of limbic (e.g., amygdalar) responses to negative stimuli has been implicated in the pathophysiology of generalized anxiety disorder (GAD). Evidence has also suggested that even a simple cognitive task involving emotionally salient stimuli can modulate limbic and prefrontal neural activation. However, whether neural modulation of emotional stimulus processing in a cognitive task is defective in adolescents with GAD has not yet been investigated. In this study, 20 adolescents with GAD and 14 comparable healthy controls underwent event-related functional magnetic resonance imaging (fMRI) coupled with an emotional valence evaluation task. During the evaluation of negative versus neutral stimuli, we found significant activation of the right inferior frontal gyrus (IFG) in healthy controls, while the bilateral amygdala was activated in GAD patients. Between-group analyses showed dramatically reduced task-activation of the right IFG in GAD patients, and the magnitude of IFG activity negatively correlated with symptom severity. Psychophysiological interaction analysis further revealed significantly decreased functional interaction between right IFG and anterior cingulate cortex and ventromedial prefrontal cortex in GAD patients compared with healthy controls. Taken together, our findings show failure to suppress negative affect by recruiting a cognitive distraction in adolescents with GAD, providing new insights into the pathophysiology of GAD.Dazhi YinWenjing LiuKristina ZeljicQian LvZhiwei WangMeina YouWeiwei MenMingxia FanWenhong ChengZheng WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dazhi Yin Wenjing Liu Kristina Zeljic Qian Lv Zhiwei Wang Meina You Weiwei Men Mingxia Fan Wenhong Cheng Zheng Wang Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
description	Abstract Hyperactivity of limbic (e.g., amygdalar) responses to negative stimuli has been implicated in the pathophysiology of generalized anxiety disorder (GAD). Evidence has also suggested that even a simple cognitive task involving emotionally salient stimuli can modulate limbic and prefrontal neural activation. However, whether neural modulation of emotional stimulus processing in a cognitive task is defective in adolescents with GAD has not yet been investigated. In this study, 20 adolescents with GAD and 14 comparable healthy controls underwent event-related functional magnetic resonance imaging (fMRI) coupled with an emotional valence evaluation task. During the evaluation of negative versus neutral stimuli, we found significant activation of the right inferior frontal gyrus (IFG) in healthy controls, while the bilateral amygdala was activated in GAD patients. Between-group analyses showed dramatically reduced task-activation of the right IFG in GAD patients, and the magnitude of IFG activity negatively correlated with symptom severity. Psychophysiological interaction analysis further revealed significantly decreased functional interaction between right IFG and anterior cingulate cortex and ventromedial prefrontal cortex in GAD patients compared with healthy controls. Taken together, our findings show failure to suppress negative affect by recruiting a cognitive distraction in adolescents with GAD, providing new insights into the pathophysiology of GAD.
format	article
author	Dazhi Yin Wenjing Liu Kristina Zeljic Qian Lv Zhiwei Wang Meina You Weiwei Men Mingxia Fan Wenhong Cheng Zheng Wang
author_facet	Dazhi Yin Wenjing Liu Kristina Zeljic Qian Lv Zhiwei Wang Meina You Weiwei Men Mingxia Fan Wenhong Cheng Zheng Wang
author_sort	Dazhi Yin
title	Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
title_short	Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
title_full	Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
title_fullStr	Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
title_full_unstemmed	Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder
title_sort	failure in cognitive suppression of negative affect in adolescents with generalized anxiety disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/270ad6d7b0264f1bb07b2c6df1484302
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Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder

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