Limitations of gene duplication models: evolution of modules in protein interaction networks.

It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesosc...

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Autor principal:	Frank Emmert-Streib
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/270b40785f3a4928b27ee509108f72c8
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spelling	oai:doaj.org-article:270b40785f3a4928b27ee509108f72c82021-11-18T07:21:43ZLimitations of gene duplication models: evolution of modules in protein interaction networks.1932-620310.1371/journal.pone.0035531https://doaj.org/article/270b40785f3a4928b27ee509108f72c82012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22530042/?tool=EBIhttps://doaj.org/toc/1932-6203It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level.Frank Emmert-StreibPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35531 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frank Emmert-Streib Limitations of gene duplication models: evolution of modules in protein interaction networks.
description	It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level.
format	article
author	Frank Emmert-Streib
author_facet	Frank Emmert-Streib
author_sort	Frank Emmert-Streib
title	Limitations of gene duplication models: evolution of modules in protein interaction networks.
title_short	Limitations of gene duplication models: evolution of modules in protein interaction networks.
title_full	Limitations of gene duplication models: evolution of modules in protein interaction networks.
title_fullStr	Limitations of gene duplication models: evolution of modules in protein interaction networks.
title_full_unstemmed	Limitations of gene duplication models: evolution of modules in protein interaction networks.
title_sort	limitations of gene duplication models: evolution of modules in protein interaction networks.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/270b40785f3a4928b27ee509108f72c8
work_keys_str_mv	AT frankemmertstreib limitationsofgeneduplicationmodelsevolutionofmodulesinproteininteractionnetworks
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Limitations of gene duplication models: evolution of modules in protein interaction networks.

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