Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.

<h4>Background</h4>Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin...

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Autores principales:	Xin-Jie Xu, Xiao-Jing Shou, Jin Li, Mei-Xiang Jia, Ji-Shui Zhang, Yan Guo, Qing-Yun Wei, Xiu-Ting Zhang, Song-Ping Han, Rong Zhang, Ji-Sheng Han
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27105258ec6f427b9021233a80f895ad
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spelling	oai:doaj.org-article:27105258ec6f427b9021233a80f895ad2021-11-18T08:53:45ZMothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.1932-620310.1371/journal.pone.0074849https://doaj.org/article/27105258ec6f427b9021233a80f895ad2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086383/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.<h4>Methods</h4>We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children's autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).<h4>Results</h4>Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children's autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.<h4>Conclusions</h4>These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children's susceptibility to autism.Xin-Jie XuXiao-Jing ShouJin LiMei-Xiang JiaJi-Shui ZhangYan GuoQing-Yun WeiXiu-Ting ZhangSong-Ping HanRong ZhangJi-Sheng HanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74849 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin-Jie Xu Xiao-Jing Shou Jin Li Mei-Xiang Jia Ji-Shui Zhang Yan Guo Qing-Yun Wei Xiu-Ting Zhang Song-Ping Han Rong Zhang Ji-Sheng Han Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
description	<h4>Background</h4>Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.<h4>Methods</h4>We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children's autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).<h4>Results</h4>Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children's autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.<h4>Conclusions</h4>These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children's susceptibility to autism.
format	article
author	Xin-Jie Xu Xiao-Jing Shou Jin Li Mei-Xiang Jia Ji-Shui Zhang Yan Guo Qing-Yun Wei Xiu-Ting Zhang Song-Ping Han Rong Zhang Ji-Sheng Han
author_facet	Xin-Jie Xu Xiao-Jing Shou Jin Li Mei-Xiang Jia Ji-Shui Zhang Yan Guo Qing-Yun Wei Xiu-Ting Zhang Song-Ping Han Rong Zhang Ji-Sheng Han
author_sort	Xin-Jie Xu
title	Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
title_short	Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
title_full	Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
title_fullStr	Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
title_full_unstemmed	Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.
title_sort	mothers of autistic children: lower plasma levels of oxytocin and arg-vasopressin and a higher level of testosterone.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/27105258ec6f427b9021233a80f895ad
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Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.

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