Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)

World-wide, Indonesia is ranked 17th in oral cancers, with deaths reaching 2.326 cases. Of the oral cancers, 90% are squamous cell carcinoma (HSC-3). Unfortunately, conventional cancer therapy still has many ill side effects. Therefore, pharmacologists have looked for natural ingredients to prevent...

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Autores principales:	Andikoputri Sasqia Faadillah, Komariah Komariah, Roeslan M. Orliando, Ranggaini Dewi, Bustami Del Afriadi
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	reactive oxygen species encapsulation nano chitosan c. citratus leaf extract hsc-3 Medicine R
Acceso en línea:	https://doaj.org/article/2710af3bbf0b48d58a5f720dd180a283
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id	oai:doaj.org-article:2710af3bbf0b48d58a5f720dd180a283
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spelling	oai:doaj.org-article:2710af3bbf0b48d58a5f720dd180a2832021-12-05T14:11:06ZNano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)2300-667610.2478/cipms-2021-0026https://doaj.org/article/2710af3bbf0b48d58a5f720dd180a2832021-09-01T00:00:00Zhttps://doi.org/10.2478/cipms-2021-0026https://doaj.org/toc/2300-6676World-wide, Indonesia is ranked 17th in oral cancers, with deaths reaching 2.326 cases. Of the oral cancers, 90% are squamous cell carcinoma (HSC-3). Unfortunately, conventional cancer therapy still has many ill side effects. Therefore, pharmacologists have looked for natural ingredients to prevent the growth of oral cancer cells. One source is Cymbopogon citratus leaf. Research shows that the active compound of C. citratus leaf is a chemopreventive, doing so by increasing the production of re-active oxygen species (ROS) to induce apoptosis in cancer cells. The active compound of C. citratus leaf has low stability and solubility, so it is necessary to use an encapsulation matrix such as chitosan, and modify it into smaller particles to increase its effectiveness.Andikoputri Sasqia FaadillahKomariah KomariahRoeslan M. OrliandoRanggaini DewiBustami Del AfriadiSciendoarticlereactive oxygen speciesencapsulationnano chitosanc. citratus leaf extracthsc-3MedicineRENCurrent Issues in Pharmacy and Medical Sciences, Vol 34, Iss 3, Pp 134-137 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive oxygen species encapsulation nano chitosan c. citratus leaf extract hsc-3 Medicine R
spellingShingle	reactive oxygen species encapsulation nano chitosan c. citratus leaf extract hsc-3 Medicine R Andikoputri Sasqia Faadillah Komariah Komariah Roeslan M. Orliando Ranggaini Dewi Bustami Del Afriadi Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
description	World-wide, Indonesia is ranked 17th in oral cancers, with deaths reaching 2.326 cases. Of the oral cancers, 90% are squamous cell carcinoma (HSC-3). Unfortunately, conventional cancer therapy still has many ill side effects. Therefore, pharmacologists have looked for natural ingredients to prevent the growth of oral cancer cells. One source is Cymbopogon citratus leaf. Research shows that the active compound of C. citratus leaf is a chemopreventive, doing so by increasing the production of re-active oxygen species (ROS) to induce apoptosis in cancer cells. The active compound of C. citratus leaf has low stability and solubility, so it is necessary to use an encapsulation matrix such as chitosan, and modify it into smaller particles to increase its effectiveness.
format	article
author	Andikoputri Sasqia Faadillah Komariah Komariah Roeslan M. Orliando Ranggaini Dewi Bustami Del Afriadi
author_facet	Andikoputri Sasqia Faadillah Komariah Komariah Roeslan M. Orliando Ranggaini Dewi Bustami Del Afriadi
author_sort	Andikoputri Sasqia Faadillah
title	Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
title_short	Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
title_full	Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
title_fullStr	Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
title_full_unstemmed	Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)
title_sort	nano chitosan encapsulation of cymbopogon citratus leaf extract promotes ros induction leading to apoptosis in human squamous cells (hsc-3)
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/2710af3bbf0b48d58a5f720dd180a283
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Nano chitosan encapsulation of Cymbopogon citratus leaf extract promotes ROS induction leading to apoptosis in human squamous cells (HSC-3)

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