Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were ass...
Guardado en:
Autores principales: | , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:2713a5886b2542e5baaa1d712a24ecfd |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:2713a5886b2542e5baaa1d712a24ecfd2021-12-02T16:57:57ZHypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model10.1038/s41598-021-89336-82045-2322https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89336-8https://doaj.org/toc/2045-2322Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, k el and k ep ) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability k ep values from 16 weeks (p < 0.05), lower venous washout k el value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.Guo-Shu HuangYi-Jen PengYu-Juei HsuHerng-Sheng LeeYue-Cune ChangShih-Wei ChiangYi-Chih HsuYing-Chun LiuMing-Huang LinChao-Ying WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
description |
Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, k el and k ep ) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability k ep values from 16 weeks (p < 0.05), lower venous washout k el value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression. |
format |
article |
author |
Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang |
author_facet |
Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang |
author_sort |
Guo-Shu Huang |
title |
Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
title_short |
Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
title_full |
Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
title_fullStr |
Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
title_full_unstemmed |
Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
title_sort |
hypoperfusion of the infrapatellar fat pad and its relationship to mri t2* relaxation time changes in a 5/6 nephrectomy model |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd |
work_keys_str_mv |
AT guoshuhuang hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT yijenpeng hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT yujueihsu hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT herngshenglee hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT yuecunechang hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT shihweichiang hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT yichihhsu hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT yingchunliu hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT minghuanglin hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel AT chaoyingwang hypoperfusionoftheinfrapatellarfatpadanditsrelationshiptomrit2relaxationtimechangesina56nephrectomymodel |
_version_ |
1718382436583211008 |