Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model

Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were ass...

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Autores principales:	Guo-Shu Huang, Yi-Jen Peng, Yu-Juei Hsu, Herng-Sheng Lee, Yue-Cune Chang, Shih-Wei Chiang, Yi-Chih Hsu, Ying-Chun Liu, Ming-Huang Lin, Chao-Ying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd
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spelling	oai:doaj.org-article:2713a5886b2542e5baaa1d712a24ecfd2021-12-02T16:57:57ZHypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model10.1038/s41598-021-89336-82045-2322https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89336-8https://doaj.org/toc/2045-2322Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, k el and k ep ) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability k ep values from 16 weeks (p < 0.05), lower venous washout k el value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.Guo-Shu HuangYi-Jen PengYu-Juei HsuHerng-Sheng LeeYue-Cune ChangShih-Wei ChiangYi-Chih HsuYing-Chun LiuMing-Huang LinChao-Ying WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
description	Abstract The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, k el and k ep ) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability k ep values from 16 weeks (p < 0.05), lower venous washout k el value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.
format	article
author	Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang
author_facet	Guo-Shu Huang Yi-Jen Peng Yu-Juei Hsu Herng-Sheng Lee Yue-Cune Chang Shih-Wei Chiang Yi-Chih Hsu Ying-Chun Liu Ming-Huang Lin Chao-Ying Wang
author_sort	Guo-Shu Huang
title	Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
title_short	Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
title_full	Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
title_fullStr	Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
title_full_unstemmed	Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
title_sort	hypoperfusion of the infrapatellar fat pad and its relationship to mri t2* relaxation time changes in a 5/6 nephrectomy model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2713a5886b2542e5baaa1d712a24ecfd
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Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model

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