20S proteasomes secreted by the malaria parasite promote its growth
Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion.
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2021
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oai:doaj.org-article:2714bdc7c6d440079ba403f2120173c12021-12-02T14:03:40Z20S proteasomes secreted by the malaria parasite promote its growth10.1038/s41467-021-21344-82041-1723https://doaj.org/article/2714bdc7c6d440079ba403f2120173c12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21344-8https://doaj.org/toc/2041-1723Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion.Elya DekelDana YaffeIrit Rosenhek-GoldianGili Ben-NissanYifat Ofir-BirinMattia I. MorandiTamar ZivXavier SisquellaMatthew A. PimentelThomas NeblEugene KappYael Ohana DanielPaula Abou KaramDaniel AlfandariRon RotkopfShimrit MalihiTal Block TeminDebakshi MullickOr-Yam RevachAriel RudikNir S. GovIdo AzuriZiv PoratGiulia BergamaschiRaya SorkinGijs J. L. WuiteOri AvinoamTeresa G. CarvalhoSidney R. CohenMichal SharonNeta Regev-RudzkiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Elya Dekel Dana Yaffe Irit Rosenhek-Goldian Gili Ben-Nissan Yifat Ofir-Birin Mattia I. Morandi Tamar Ziv Xavier Sisquella Matthew A. Pimentel Thomas Nebl Eugene Kapp Yael Ohana Daniel Paula Abou Karam Daniel Alfandari Ron Rotkopf Shimrit Malihi Tal Block Temin Debakshi Mullick Or-Yam Revach Ariel Rudik Nir S. Gov Ido Azuri Ziv Porat Giulia Bergamaschi Raya Sorkin Gijs J. L. Wuite Ori Avinoam Teresa G. Carvalho Sidney R. Cohen Michal Sharon Neta Regev-Rudzki 20S proteasomes secreted by the malaria parasite promote its growth |
| description |
Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion. |
| format |
article |
| author |
Elya Dekel Dana Yaffe Irit Rosenhek-Goldian Gili Ben-Nissan Yifat Ofir-Birin Mattia I. Morandi Tamar Ziv Xavier Sisquella Matthew A. Pimentel Thomas Nebl Eugene Kapp Yael Ohana Daniel Paula Abou Karam Daniel Alfandari Ron Rotkopf Shimrit Malihi Tal Block Temin Debakshi Mullick Or-Yam Revach Ariel Rudik Nir S. Gov Ido Azuri Ziv Porat Giulia Bergamaschi Raya Sorkin Gijs J. L. Wuite Ori Avinoam Teresa G. Carvalho Sidney R. Cohen Michal Sharon Neta Regev-Rudzki |
| author_facet |
Elya Dekel Dana Yaffe Irit Rosenhek-Goldian Gili Ben-Nissan Yifat Ofir-Birin Mattia I. Morandi Tamar Ziv Xavier Sisquella Matthew A. Pimentel Thomas Nebl Eugene Kapp Yael Ohana Daniel Paula Abou Karam Daniel Alfandari Ron Rotkopf Shimrit Malihi Tal Block Temin Debakshi Mullick Or-Yam Revach Ariel Rudik Nir S. Gov Ido Azuri Ziv Porat Giulia Bergamaschi Raya Sorkin Gijs J. L. Wuite Ori Avinoam Teresa G. Carvalho Sidney R. Cohen Michal Sharon Neta Regev-Rudzki |
| author_sort |
Elya Dekel |
| title |
20S proteasomes secreted by the malaria parasite promote its growth |
| title_short |
20S proteasomes secreted by the malaria parasite promote its growth |
| title_full |
20S proteasomes secreted by the malaria parasite promote its growth |
| title_fullStr |
20S proteasomes secreted by the malaria parasite promote its growth |
| title_full_unstemmed |
20S proteasomes secreted by the malaria parasite promote its growth |
| title_sort |
20s proteasomes secreted by the malaria parasite promote its growth |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2714bdc7c6d440079ba403f2120173c1 |
| work_keys_str_mv |
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