Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores

Aerolysin pores have potential to improve the accuracy of DNA sequencing and single-molecule proteomics. Here, the authors rationally design a set of mutated pores to achieve a more accurate detection of peptides and nucleic acids.

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Detalles Bibliográficos
Autores principales: Chan Cao, Nuria Cirauqui, Maria Jose Marcaida, Elena Buglakova, Alice Duperrex, Aleksandra Radenovic, Matteo Dal Peraro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/27165b7a4d1542c79d4bf6e6931d454d
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Sumario:Aerolysin pores have potential to improve the accuracy of DNA sequencing and single-molecule proteomics. Here, the authors rationally design a set of mutated pores to achieve a more accurate detection of peptides and nucleic acids.