Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

ABSTRACT Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and a...

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Autores principales:	David S. Fedson, Jeffrey R. Jacobson, Ole Martin Rordam, Steven M. Opal
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/27173e9602ba445d929bca6c1f08fdec
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spelling	oai:doaj.org-article:27173e9602ba445d929bca6c1f08fdec2021-11-15T15:49:03ZTreating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers10.1128/mBio.00716-152150-7511https://doaj.org/article/27173e9602ba445d929bca6c1f08fdec2015-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00716-15https://doaj.org/toc/2150-7511ABSTRACT Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers restore endothelial barrier integrity, they can be used to treat the host response in these patients. In Sierra Leone, approximately 100 Ebola patients were treated with this combination, and reports indicate that survival was greatly improved.David S. FedsonJeffrey R. JacobsonOle Martin RordamSteven M. OpalAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 3 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 David S. Fedson Jeffrey R. Jacobson Ole Martin Rordam Steven M. Opal Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
description	ABSTRACT Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers restore endothelial barrier integrity, they can be used to treat the host response in these patients. In Sierra Leone, approximately 100 Ebola patients were treated with this combination, and reports indicate that survival was greatly improved.
format	article
author	David S. Fedson Jeffrey R. Jacobson Ole Martin Rordam Steven M. Opal
author_facet	David S. Fedson Jeffrey R. Jacobson Ole Martin Rordam Steven M. Opal
author_sort	David S. Fedson
title	Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
title_short	Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
title_full	Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
title_fullStr	Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
title_full_unstemmed	Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers
title_sort	treating the host response to ebola virus disease with generic statins and angiotensin receptor blockers
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/27173e9602ba445d929bca6c1f08fdec
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Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

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