Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study

Abstract Background Allergic rhinitis (AR) or Hay fever is a chronic inflammation of the nasal mucosa induced by IgE-mediated hypersensitivity due to exposure of various allergens. AR occurs as a response against these inhaled allergens that cause inflammation of nasal mucosal membranes. In this stu...

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Autores principales:	P. Kiruba Shankari, Swathi Suresh, Rukaiah Fatma Begum
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Allergic rhinitis Visual analogue scale Absolute eosinophil count Fluticasone propionate Budesonide Intranasal corticosteroids Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/271bc3e477b64f4f99d00fdfc4e7bccb
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spelling	oai:doaj.org-article:271bc3e477b64f4f99d00fdfc4e7bccb2021-11-28T12:06:05ZEfficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study10.1186/s43163-021-00181-y1012-55742090-8539https://doaj.org/article/271bc3e477b64f4f99d00fdfc4e7bccb2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43163-021-00181-yhttps://doaj.org/toc/1012-5574https://doaj.org/toc/2090-8539Abstract Background Allergic rhinitis (AR) or Hay fever is a chronic inflammation of the nasal mucosa induced by IgE-mediated hypersensitivity due to exposure of various allergens. AR occurs as a response against these inhaled allergens that cause inflammation of nasal mucosal membranes. In this study, a reliable treatment for allergic rhinitis with maximum effectiveness and minimal side effects was assessed. This study compared the effectiveness of intranasal Fluticasone propionate (FUP) and intranasal Budesonide (BUD) in reducing the eosinophil count and in improving the nasal and ocular symptoms. This prospective study was conducted on 62 cases of allergic rhinitis and patients with mild-to-moderate allergic rhinitis were selected for the study. They were randomly divided into two groups; group I consists of 30 patients who received intranasal Fluticasone propionate aqueous spray, total daily dose of 200 μg (50 μg/spray) as 2 sprays in each nostril administered once daily, whereas the group II consists of 32 patients who received intranasal Budesonide aqueous spray, total daily dose of 400 μg/day (100 μg/spray) as 1 spray in each nostril administered twice daily. Results Analysis on patient-based symptom scores revealed that both the groups showed statistically significant reduction in symptoms. Fluticasone propionate was found to be significantly more effective (P < 0.05) than Budesonide in reducing sneezing, nasal itching and majority of symptoms of individual symptom scores. Budesonide showed somewhat similar effect in reducing nasal blockage at 4 weeks of treatment. Conclusion Clinically, both the drugs showed statistically significant improvement when compared to baseline, but Fluticasone propionate was superior at reducing nasal symptoms, ocular symptom and eosinophil count.P. Kiruba ShankariSwathi SureshRukaiah Fatma BegumSpringerOpenarticleAllergic rhinitisVisual analogue scaleAbsolute eosinophil countFluticasone propionateBudesonideIntranasal corticosteroidsOtorhinolaryngologyRF1-547ENThe Egyptian Journal of Otolaryngology, Vol 37, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Allergic rhinitis Visual analogue scale Absolute eosinophil count Fluticasone propionate Budesonide Intranasal corticosteroids Otorhinolaryngology RF1-547
spellingShingle	Allergic rhinitis Visual analogue scale Absolute eosinophil count Fluticasone propionate Budesonide Intranasal corticosteroids Otorhinolaryngology RF1-547 P. Kiruba Shankari Swathi Suresh Rukaiah Fatma Begum Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
description	Abstract Background Allergic rhinitis (AR) or Hay fever is a chronic inflammation of the nasal mucosa induced by IgE-mediated hypersensitivity due to exposure of various allergens. AR occurs as a response against these inhaled allergens that cause inflammation of nasal mucosal membranes. In this study, a reliable treatment for allergic rhinitis with maximum effectiveness and minimal side effects was assessed. This study compared the effectiveness of intranasal Fluticasone propionate (FUP) and intranasal Budesonide (BUD) in reducing the eosinophil count and in improving the nasal and ocular symptoms. This prospective study was conducted on 62 cases of allergic rhinitis and patients with mild-to-moderate allergic rhinitis were selected for the study. They were randomly divided into two groups; group I consists of 30 patients who received intranasal Fluticasone propionate aqueous spray, total daily dose of 200 μg (50 μg/spray) as 2 sprays in each nostril administered once daily, whereas the group II consists of 32 patients who received intranasal Budesonide aqueous spray, total daily dose of 400 μg/day (100 μg/spray) as 1 spray in each nostril administered twice daily. Results Analysis on patient-based symptom scores revealed that both the groups showed statistically significant reduction in symptoms. Fluticasone propionate was found to be significantly more effective (P < 0.05) than Budesonide in reducing sneezing, nasal itching and majority of symptoms of individual symptom scores. Budesonide showed somewhat similar effect in reducing nasal blockage at 4 weeks of treatment. Conclusion Clinically, both the drugs showed statistically significant improvement when compared to baseline, but Fluticasone propionate was superior at reducing nasal symptoms, ocular symptom and eosinophil count.
format	article
author	P. Kiruba Shankari Swathi Suresh Rukaiah Fatma Begum
author_facet	P. Kiruba Shankari Swathi Suresh Rukaiah Fatma Begum
author_sort	P. Kiruba Shankari
title	Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
title_short	Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
title_full	Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
title_fullStr	Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
title_full_unstemmed	Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
title_sort	efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/271bc3e477b64f4f99d00fdfc4e7bccb
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Efficacy of intranasal fluticasone propionate and budesonide in management of allergic rhinitis—a prospective comparative study

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