Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia

Background. We studied the effect of combined application of omega-3 polyunsaturated fatty acid concentrate, based on seals fat, with parenteral administration of brain cortex polypeptide preparation on cognitive-research reactions and adaptation of rats under experimental hyperlipidemia. The compos...

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Autores principales:	Tatyana I. Sangadieva, Galina P. Lamazhapova, Erzhena V. Syngeeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	cortexin polyunsaturated fatty acids hyperlipidemia neuroprotection Science Q
Acceso en línea:	https://doaj.org/article/272009c05c7a408bac44b39e66b69c65
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spelling	oai:doaj.org-article:272009c05c7a408bac44b39e66b69c652021-11-23T06:14:42ZNootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia2541-94202587-959610.29413/ABS.2019-4.1.23https://doaj.org/article/272009c05c7a408bac44b39e66b69c652019-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1992https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. We studied the effect of combined application of omega-3 polyunsaturated fatty acid concentrate, based on seals fat, with parenteral administration of brain cortex polypeptide preparation on cognitive-research reactions and adaptation of rats under experimental hyperlipidemia. The composition of the myelin sheaths of neurons is represented by a protein-lipid complex, which is a part of the cell membrane, the imbalance of which leads to a number of neurological diseases.The aim of the study was to confirm experimentally that the combined use of drugs, based on essential polyunsaturated fatty acids and polypeptides, would influence more effectively on neurometabolic processes in neurons, compared to their application separately.Materials and methods. Wistar rats were used. They were on a special atherogenic diet to build the model of hypercholesterolemia. The pharmacological effects of drugs were evaluated in the Open Field and Morris Water Maze tests.Results. The study found that in rats, who received a combination of polyunsaturated fatty acids concentrate with Cortexin injections, and undergoing atherogenic diet, the overall motor activity increased significantly in the Open field test, at the same time the number of acts of defecation and grooming decreased. The Morris Water Maze test results indicated an increase in the level of spatial memory and orientation, which shows a high level of adaptability and adaptation to new conditions, a decrease in the level of anxiety.Conclusions. The results demonstrated a more pronounced and prolonged nootropic and adaptogenic action of the complex use in comparison with the use of the studied agents as monotherapy.Tatyana I. SangadievaGalina P. LamazhapovaErzhena V. SyngeevaScientific Сentre for Family Health and Human Reproduction Problemsarticlecortexinpolyunsaturated fatty acidshyperlipidemianeuroprotectionScienceQRUActa Biomedica Scientifica, Vol 4, Iss 1, Pp 150-154 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	cortexin polyunsaturated fatty acids hyperlipidemia neuroprotection Science Q
spellingShingle	cortexin polyunsaturated fatty acids hyperlipidemia neuroprotection Science Q Tatyana I. Sangadieva Galina P. Lamazhapova Erzhena V. Syngeeva Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
description	Background. We studied the effect of combined application of omega-3 polyunsaturated fatty acid concentrate, based on seals fat, with parenteral administration of brain cortex polypeptide preparation on cognitive-research reactions and adaptation of rats under experimental hyperlipidemia. The composition of the myelin sheaths of neurons is represented by a protein-lipid complex, which is a part of the cell membrane, the imbalance of which leads to a number of neurological diseases.The aim of the study was to confirm experimentally that the combined use of drugs, based on essential polyunsaturated fatty acids and polypeptides, would influence more effectively on neurometabolic processes in neurons, compared to their application separately.Materials and methods. Wistar rats were used. They were on a special atherogenic diet to build the model of hypercholesterolemia. The pharmacological effects of drugs were evaluated in the Open Field and Morris Water Maze tests.Results. The study found that in rats, who received a combination of polyunsaturated fatty acids concentrate with Cortexin injections, and undergoing atherogenic diet, the overall motor activity increased significantly in the Open field test, at the same time the number of acts of defecation and grooming decreased. The Morris Water Maze test results indicated an increase in the level of spatial memory and orientation, which shows a high level of adaptability and adaptation to new conditions, a decrease in the level of anxiety.Conclusions. The results demonstrated a more pronounced and prolonged nootropic and adaptogenic action of the complex use in comparison with the use of the studied agents as monotherapy.
format	article
author	Tatyana I. Sangadieva Galina P. Lamazhapova Erzhena V. Syngeeva
author_facet	Tatyana I. Sangadieva Galina P. Lamazhapova Erzhena V. Syngeeva
author_sort	Tatyana I. Sangadieva
title	Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
title_short	Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
title_full	Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
title_fullStr	Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
title_full_unstemmed	Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia
title_sort	nootropic and adaptogenic effect of combined use of cortexin with polyunsaturated fatty acids concentrate under experimental dislipidemia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/272009c05c7a408bac44b39e66b69c65
work_keys_str_mv	AT tatyanaisangadieva nootropicandadaptogeniceffectofcombineduseofcortexinwithpolyunsaturatedfattyacidsconcentrateunderexperimentaldislipidemia AT galinaplamazhapova nootropicandadaptogeniceffectofcombineduseofcortexinwithpolyunsaturatedfattyacidsconcentrateunderexperimentaldislipidemia AT erzhenavsyngeeva nootropicandadaptogeniceffectofcombineduseofcortexinwithpolyunsaturatedfattyacidsconcentrateunderexperimentaldislipidemia
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Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia

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