Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series

Fares Antaki,1,2,* Simon Javidi,1,2,* Samir Touma,1 Marie-Josée Aubin1– 3 1Centre Universitaire d’Ophtalmologie (CUO), Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est-de-L’île-de-Montréal, Montreal, Quebec, Canada; 2Depa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Antaki F, Javidi S, Touma S, Aubin MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	systematic review tuberculosis endophthalmitis panophthalmitis panuveitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/272419af871e4a5bb36b3592be0847ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:272419af871e4a5bb36b3592be0847ef
record_format	dspace
spelling	oai:doaj.org-article:272419af871e4a5bb36b3592be0847ef2021-12-02T13:16:05ZEndogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series1177-5483https://doaj.org/article/272419af871e4a5bb36b3592be0847ef2020-10-01T00:00:00Zhttps://www.dovepress.com/endogenous-tuberculous-endophthalmitis-and-panophthalmitis-a-systemati-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fares Antaki,1,2,* Simon Javidi,1,2,* Samir Touma,1 Marie-Josée Aubin1– 3 1Centre Universitaire d’Ophtalmologie (CUO), Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est-de-L’île-de-Montréal, Montreal, Quebec, Canada; 2Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada; 3Department of Social and Preventive Medicine, School of Public Health, Université de Montréal, Montreal, Quebec, Canada*These authors contributed equally to this workCorrespondence: Fares AntakiDepartment of Ophthalmology, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est-de-L’île-de-Montréal, 5415 Assumption Blvd, Montreal, QC H1T 2M4, CanadaEmail fares.antaki@umontreal.caPurpose: To systematically review the characteristics of patients with endogenous tuberculous (TB) endophthalmitis and panophthalmitis in an effort to help clinicians with diagnosis and treatment.Patients and Methods: We conducted a systematic literature search in MEDLINE/PubMed, EMBASE and Web of Science from inception to August 2020. References and abstracts were screened independently by two authors. Included studies were case reports and case series reporting endogenous TB endophthalmitis and panophthalmitis secondary to Mycobacterium tuberculosis complex (MTBC). Available-case analysis was employed to handle missing data. Results: A total of 1343 articles were found using the search strategy. Following abstract screening, 51 articles were selected for full text-review, from which 26 were deemed eligible for inclusion in the study. Forty-four cases from 26 articles were included in the quantitative analysis. The median age of presentation was 29.5 (range: 1 to 81), and 11/44 patients (25.0%) were pediatric. Immunosuppression was seen in 9/36 cases (25.0%). Most patients (24/38, 63.2%) had no prior history of tuberculosis. Systemic symptoms were absent in half of the patients (16/32, 50.0%). Visual acuity was poor, with 23/27 cases (85.2%) being 20/200 or worse at presentation. Poor organ and visual outcomes were reported: 36/43 cases (83.7%) resulted in enucleation/evisceration or exenteration. Intraocular tumors were suspected in 5/34 cases (14.7%). Pulmonary tuberculosis was seen in 15/35 cases (42.8%), and miliary tuberculosis was seen in 7/35 cases (20.0%). The earliest source of TB diagnosis was through histopathologic specimen after eye removal in 32/44 cases (72.7%), vitreous specimen in 6/44 cases (13.6%) and aqueous specimen in 3/44 cases (6.8%).Conclusion: TB endophthalmitis is a rare and sight-threatening manifestation of ocular tuberculosis. It can occur in apparently healthy individuals and can mimic intraocular tumors and other infectious etiologies. Diagnosis remains a significant challenge, which, often delayed, leads to profound visual loss. Early detection and treatment of intraocular tuberculosis may be associated with better ocular and systemic outcomes.Keywords: systematic review, tuberculosis, endophthalmitis, panophthalmitis, panuveitisAntaki FJavidi STouma SAubin MJDove Medical Pressarticlesystematic reviewtuberculosisendophthalmitispanophthalmitispanuveitisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3075-3096 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	systematic review tuberculosis endophthalmitis panophthalmitis panuveitis Ophthalmology RE1-994
spellingShingle	systematic review tuberculosis endophthalmitis panophthalmitis panuveitis Ophthalmology RE1-994 Antaki F Javidi S Touma S Aubin MJ Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
description	Fares Antaki,1,2,* Simon Javidi,1,2,* Samir Touma,1 Marie-Josée Aubin1– 3 1Centre Universitaire d’Ophtalmologie (CUO), Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est-de-L’île-de-Montréal, Montreal, Quebec, Canada; 2Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada; 3Department of Social and Preventive Medicine, School of Public Health, Université de Montréal, Montreal, Quebec, Canada*These authors contributed equally to this workCorrespondence: Fares AntakiDepartment of Ophthalmology, Hôpital Maisonneuve-Rosemont, CIUSSS de l’Est-de-L’île-de-Montréal, 5415 Assumption Blvd, Montreal, QC H1T 2M4, CanadaEmail fares.antaki@umontreal.caPurpose: To systematically review the characteristics of patients with endogenous tuberculous (TB) endophthalmitis and panophthalmitis in an effort to help clinicians with diagnosis and treatment.Patients and Methods: We conducted a systematic literature search in MEDLINE/PubMed, EMBASE and Web of Science from inception to August 2020. References and abstracts were screened independently by two authors. Included studies were case reports and case series reporting endogenous TB endophthalmitis and panophthalmitis secondary to Mycobacterium tuberculosis complex (MTBC). Available-case analysis was employed to handle missing data. Results: A total of 1343 articles were found using the search strategy. Following abstract screening, 51 articles were selected for full text-review, from which 26 were deemed eligible for inclusion in the study. Forty-four cases from 26 articles were included in the quantitative analysis. The median age of presentation was 29.5 (range: 1 to 81), and 11/44 patients (25.0%) were pediatric. Immunosuppression was seen in 9/36 cases (25.0%). Most patients (24/38, 63.2%) had no prior history of tuberculosis. Systemic symptoms were absent in half of the patients (16/32, 50.0%). Visual acuity was poor, with 23/27 cases (85.2%) being 20/200 or worse at presentation. Poor organ and visual outcomes were reported: 36/43 cases (83.7%) resulted in enucleation/evisceration or exenteration. Intraocular tumors were suspected in 5/34 cases (14.7%). Pulmonary tuberculosis was seen in 15/35 cases (42.8%), and miliary tuberculosis was seen in 7/35 cases (20.0%). The earliest source of TB diagnosis was through histopathologic specimen after eye removal in 32/44 cases (72.7%), vitreous specimen in 6/44 cases (13.6%) and aqueous specimen in 3/44 cases (6.8%).Conclusion: TB endophthalmitis is a rare and sight-threatening manifestation of ocular tuberculosis. It can occur in apparently healthy individuals and can mimic intraocular tumors and other infectious etiologies. Diagnosis remains a significant challenge, which, often delayed, leads to profound visual loss. Early detection and treatment of intraocular tuberculosis may be associated with better ocular and systemic outcomes.Keywords: systematic review, tuberculosis, endophthalmitis, panophthalmitis, panuveitis
format	article
author	Antaki F Javidi S Touma S Aubin MJ
author_facet	Antaki F Javidi S Touma S Aubin MJ
author_sort	Antaki F
title	Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
title_short	Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
title_full	Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
title_fullStr	Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
title_full_unstemmed	Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series
title_sort	endogenous tuberculous endophthalmitis and panophthalmitis: a systematic review of case reports and case series
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/272419af871e4a5bb36b3592be0847ef
work_keys_str_mv	AT antakif endogenoustuberculousendophthalmitisandpanophthalmitisasystematicreviewofcasereportsandcaseseries AT javidis endogenoustuberculousendophthalmitisandpanophthalmitisasystematicreviewofcasereportsandcaseseries AT toumas endogenoustuberculousendophthalmitisandpanophthalmitisasystematicreviewofcasereportsandcaseseries AT aubinmj endogenoustuberculousendophthalmitisandpanophthalmitisasystematicreviewofcasereportsandcaseseries
_version_	1718393321871638528

Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series

Ejemplares similares