Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis

Abstract We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)—derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assess...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sang Jin Lee, Chae Moon Hong, Il Cho, Byeong-Cheol Ahn, Jung Su Eun, Na Ri Kim, Jong Whan Kang, Young Mo Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2724d2482aa340c3bdb3714f680c718f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2724d2482aa340c3bdb3714f680c718f
record_format	dspace
spelling	oai:doaj.org-article:2724d2482aa340c3bdb3714f680c718f2021-11-14T12:21:15ZReappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis10.1038/s41598-021-01104-w2045-2322https://doaj.org/article/2724d2482aa340c3bdb3714f680c718f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01104-whttps://doaj.org/toc/2045-2322Abstract We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)—derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assessment in patients with rheumatoid arthritis (RA). We enrolled 106 patients (67 in the development group and 39 in the validation groups) with active RA who underwent BS, 18F-FDG PET/computed tomography (CT), and clinical evaluation of disease activity. We compared the results of BS-derived joint assessment with those of PET-derived and clinical joint assessments. Subsequently we developed a disease activity score (DAS) using BS-positive joints and validated it in an independent group. The number of BS-positive joints in 28-joint areas significantly correlated with the swollen /tender joint counts (SJC/TJC) and PET-derived joint counts. A BS uptake score of 2 (strong positive) was significantly more sensitive compared with a BS uptake score of 1 (weak positive) in detecting a PET-positive joint among the 28-joints. After conducting multivariate analyses including erythrocyte sediment rate (ESR) and patient global assessment (PGA) in addition to BS-derived parameters, BS/DAS was obtained as follows: 0.056 × number of BS-positive joints in 28 joints + 0.012 × ESR + 0.030 × PGA. A significant correlation between BS/DAS and DAS28-ESR was confirmed in the validation group. Strong positive uptake of BS is sensitive and reproducible for the detection of active joints, and can complement the clinical assessment of disease activity in RA.Sang Jin LeeChae Moon HongIl ChoByeong-Cheol AhnJung Su EunNa Ri KimJong Whan KangYoung Mo KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Jin Lee Chae Moon Hong Il Cho Byeong-Cheol Ahn Jung Su Eun Na Ri Kim Jong Whan Kang Young Mo Kang Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
description	Abstract We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)—derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assessment in patients with rheumatoid arthritis (RA). We enrolled 106 patients (67 in the development group and 39 in the validation groups) with active RA who underwent BS, 18F-FDG PET/computed tomography (CT), and clinical evaluation of disease activity. We compared the results of BS-derived joint assessment with those of PET-derived and clinical joint assessments. Subsequently we developed a disease activity score (DAS) using BS-positive joints and validated it in an independent group. The number of BS-positive joints in 28-joint areas significantly correlated with the swollen /tender joint counts (SJC/TJC) and PET-derived joint counts. A BS uptake score of 2 (strong positive) was significantly more sensitive compared with a BS uptake score of 1 (weak positive) in detecting a PET-positive joint among the 28-joints. After conducting multivariate analyses including erythrocyte sediment rate (ESR) and patient global assessment (PGA) in addition to BS-derived parameters, BS/DAS was obtained as follows: 0.056 × number of BS-positive joints in 28 joints + 0.012 × ESR + 0.030 × PGA. A significant correlation between BS/DAS and DAS28-ESR was confirmed in the validation group. Strong positive uptake of BS is sensitive and reproducible for the detection of active joints, and can complement the clinical assessment of disease activity in RA.
format	article
author	Sang Jin Lee Chae Moon Hong Il Cho Byeong-Cheol Ahn Jung Su Eun Na Ri Kim Jong Whan Kang Young Mo Kang
author_facet	Sang Jin Lee Chae Moon Hong Il Cho Byeong-Cheol Ahn Jung Su Eun Na Ri Kim Jong Whan Kang Young Mo Kang
author_sort	Sang Jin Lee
title	Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
title_short	Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
title_full	Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
title_fullStr	Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
title_full_unstemmed	Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
title_sort	reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2724d2482aa340c3bdb3714f680c718f
work_keys_str_mv	AT sangjinlee reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT chaemoonhong reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT ilcho reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT byeongcheolahn reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT jungsueun reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT narikim reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT jongwhankang reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis AT youngmokang reappraisalofbonescintigraphyasanewtoolfortheevaluationofdiseaseactivityinpatientswithrheumatoidarthritis
_version_	1718429216982171648

Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis

Ejemplares similares