Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review

Estelle De Groote, Louise Deldicque Institute of Neuroscience, Université catholique de Louvain, Louvain-la-Neuve, BelgiumCorrespondence: Louise DeldicqueInstitute of Neuroscience, Université catholique de Louvain, Place Pierre de Coubertin, 1 Box L08.10.01, Louvain-la-Neuve, 1348, BelgiumTel +32 10...

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Autores principales:	De Groote E, Deldicque L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hypoxic training glucose metabolism insulin resistance obesity prediabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2726ba34f8674989800793e236693f44
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spelling	oai:doaj.org-article:2726ba34f8674989800793e236693f442021-12-02T16:38:15ZIs Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review1178-7007https://doaj.org/article/2726ba34f8674989800793e236693f442021-08-01T00:00:00Zhttps://www.dovepress.com/is-physical-exercise-in-hypoxia-an-interesting-strategy-to-prevent-the-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Estelle De Groote, Louise Deldicque Institute of Neuroscience, Université catholique de Louvain, Louvain-la-Neuve, BelgiumCorrespondence: Louise DeldicqueInstitute of Neuroscience, Université catholique de Louvain, Place Pierre de Coubertin, 1 Box L08.10.01, Louvain-la-Neuve, 1348, BelgiumTel +32 10 47 44 43Email louise.deldicque@uclouvain.beAbstract:: Impaired metabolism is becoming one of the main causes of mortality and the identification of strategies to cure those diseases is a major public health concern. A number of therapies are being developed to treat type 2 diabetes mellitus (T2DM), but few of them focus on situations prior to diabetes. Obesity, aging and insulin resistance are all risk factors, which fortunately can be reversed to some extent. Non-drug interventions, such as exercise, are interesting strategies to prevent the onset of diabetes, but it remains to determine the optimal dose and conditions. In the search of optimizing the effects of physical exercise to prevent T2DM, hypoxic training has emerged as an interesting and original strategy. Several recent studies have chosen to look at the effects of hypoxic training in people at risk of developing T2DM. Therefore, the purpose of this narrative review is to give an overview of all original articles having tested the effects of a single exercise or exercise training in hypoxia on glucose metabolism and other health-related parameters in people at risk of developing T2DM. Taken together, the data on the effects of hypoxic training on glucose metabolism, insulin sensitivity and the health status of people at risk of T2DM are inconclusive. Some studies show that hypoxic training can improve glucose metabolism and the health status to a greater extent than normoxic training, while others do not corroborate the latter. When an additional benefit of hypoxic vs normoxic training is found, it still remains to determine which signaling pathways and molecular mechanisms are involved.Keywords: hypoxic training, glucose metabolism, insulin resistance, obesity, prediabetesDe Groote EDeldicque LDove Medical Pressarticlehypoxic trainingglucose metabolisminsulin resistanceobesityprediabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3603-3616 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxic training glucose metabolism insulin resistance obesity prediabetes Specialties of internal medicine RC581-951
spellingShingle	hypoxic training glucose metabolism insulin resistance obesity prediabetes Specialties of internal medicine RC581-951 De Groote E Deldicque L Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
description	Estelle De Groote, Louise Deldicque Institute of Neuroscience, Université catholique de Louvain, Louvain-la-Neuve, BelgiumCorrespondence: Louise DeldicqueInstitute of Neuroscience, Université catholique de Louvain, Place Pierre de Coubertin, 1 Box L08.10.01, Louvain-la-Neuve, 1348, BelgiumTel +32 10 47 44 43Email louise.deldicque@uclouvain.beAbstract:: Impaired metabolism is becoming one of the main causes of mortality and the identification of strategies to cure those diseases is a major public health concern. A number of therapies are being developed to treat type 2 diabetes mellitus (T2DM), but few of them focus on situations prior to diabetes. Obesity, aging and insulin resistance are all risk factors, which fortunately can be reversed to some extent. Non-drug interventions, such as exercise, are interesting strategies to prevent the onset of diabetes, but it remains to determine the optimal dose and conditions. In the search of optimizing the effects of physical exercise to prevent T2DM, hypoxic training has emerged as an interesting and original strategy. Several recent studies have chosen to look at the effects of hypoxic training in people at risk of developing T2DM. Therefore, the purpose of this narrative review is to give an overview of all original articles having tested the effects of a single exercise or exercise training in hypoxia on glucose metabolism and other health-related parameters in people at risk of developing T2DM. Taken together, the data on the effects of hypoxic training on glucose metabolism, insulin sensitivity and the health status of people at risk of T2DM are inconclusive. Some studies show that hypoxic training can improve glucose metabolism and the health status to a greater extent than normoxic training, while others do not corroborate the latter. When an additional benefit of hypoxic vs normoxic training is found, it still remains to determine which signaling pathways and molecular mechanisms are involved.Keywords: hypoxic training, glucose metabolism, insulin resistance, obesity, prediabetes
format	article
author	De Groote E Deldicque L
author_facet	De Groote E Deldicque L
author_sort	De Groote E
title	Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
title_short	Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
title_full	Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
title_fullStr	Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
title_full_unstemmed	Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review
title_sort	is physical exercise in hypoxia an interesting strategy to prevent the development of type 2 diabetes? a narrative review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2726ba34f8674989800793e236693f44
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Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review

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