An ERP study on proactive and reactive response inhibition in individuals with schizotypy

Abstract Schizotypy, a subclinical group at risk for schizophrenia, has been found to show impairments in response inhibition. However, it remains unclear whether this impairment is accompanied by outright stopping (reactive inhibition) or preparation for stopping (proactive inhibition). We recruite...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lu-xia Jia, Xiao-jing Qin, Ji-fang Cui, Qi Zheng, Tian-xiao Yang, Ya Wang, Raymond C. K. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2728cc3aa633490cb8df8f498fc13a2b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2728cc3aa633490cb8df8f498fc13a2b
record_format	dspace
spelling	oai:doaj.org-article:2728cc3aa633490cb8df8f498fc13a2b2021-12-02T18:03:15ZAn ERP study on proactive and reactive response inhibition in individuals with schizotypy10.1038/s41598-021-87735-52045-2322https://doaj.org/article/2728cc3aa633490cb8df8f498fc13a2b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87735-5https://doaj.org/toc/2045-2322Abstract Schizotypy, a subclinical group at risk for schizophrenia, has been found to show impairments in response inhibition. However, it remains unclear whether this impairment is accompanied by outright stopping (reactive inhibition) or preparation for stopping (proactive inhibition). We recruited 20 schizotypy and 24 non-schizotypy individuals to perform a modified stop-signal task with electroencephalographic (EEG) data recorded. This task consists of three conditions based on the probability of stop signal: 0% (no stop trials, only go trials), 17% (17% stop trials), and 33% (33% stop trials), the conditions were indicated by the colour of go stimuli. For proactive inhibition (go trials), individuals with schizotypy exhibited significantly lesser increase in go response time (RT) as the stop signal probability increasing compared to non-schizotypy individuals. Individuals with schizotypy also exhibited significantly increased N1 amplitude on all levels of stop signal probability and increased P3 amplitude in the 17% stop condition compared with non-schizotypy individuals. For reactive inhibition (stop trials), individuals with schizotypy exhibited significantly longer stop signal reaction time (SSRT) in both 17% and 33% stop conditions and smaller N2 amplitude on stop trials in the 17% stop condition than non-schizotypy individuals. These findings suggest that individuals with schizotypy were impaired in both proactive and reactive response inhibition at behavioural and neural levels.Lu-xia JiaXiao-jing QinJi-fang CuiQi ZhengTian-xiao YangYa WangRaymond C. K. ChanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lu-xia Jia Xiao-jing Qin Ji-fang Cui Qi Zheng Tian-xiao Yang Ya Wang Raymond C. K. Chan An ERP study on proactive and reactive response inhibition in individuals with schizotypy
description	Abstract Schizotypy, a subclinical group at risk for schizophrenia, has been found to show impairments in response inhibition. However, it remains unclear whether this impairment is accompanied by outright stopping (reactive inhibition) or preparation for stopping (proactive inhibition). We recruited 20 schizotypy and 24 non-schizotypy individuals to perform a modified stop-signal task with electroencephalographic (EEG) data recorded. This task consists of three conditions based on the probability of stop signal: 0% (no stop trials, only go trials), 17% (17% stop trials), and 33% (33% stop trials), the conditions were indicated by the colour of go stimuli. For proactive inhibition (go trials), individuals with schizotypy exhibited significantly lesser increase in go response time (RT) as the stop signal probability increasing compared to non-schizotypy individuals. Individuals with schizotypy also exhibited significantly increased N1 amplitude on all levels of stop signal probability and increased P3 amplitude in the 17% stop condition compared with non-schizotypy individuals. For reactive inhibition (stop trials), individuals with schizotypy exhibited significantly longer stop signal reaction time (SSRT) in both 17% and 33% stop conditions and smaller N2 amplitude on stop trials in the 17% stop condition than non-schizotypy individuals. These findings suggest that individuals with schizotypy were impaired in both proactive and reactive response inhibition at behavioural and neural levels.
format	article
author	Lu-xia Jia Xiao-jing Qin Ji-fang Cui Qi Zheng Tian-xiao Yang Ya Wang Raymond C. K. Chan
author_facet	Lu-xia Jia Xiao-jing Qin Ji-fang Cui Qi Zheng Tian-xiao Yang Ya Wang Raymond C. K. Chan
author_sort	Lu-xia Jia
title	An ERP study on proactive and reactive response inhibition in individuals with schizotypy
title_short	An ERP study on proactive and reactive response inhibition in individuals with schizotypy
title_full	An ERP study on proactive and reactive response inhibition in individuals with schizotypy
title_fullStr	An ERP study on proactive and reactive response inhibition in individuals with schizotypy
title_full_unstemmed	An ERP study on proactive and reactive response inhibition in individuals with schizotypy
title_sort	erp study on proactive and reactive response inhibition in individuals with schizotypy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2728cc3aa633490cb8df8f498fc13a2b
work_keys_str_mv	AT luxiajia anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT xiaojingqin anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT jifangcui anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT qizheng anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT tianxiaoyang anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT yawang anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT raymondckchan anerpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT luxiajia erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT xiaojingqin erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT jifangcui erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT qizheng erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT tianxiaoyang erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT yawang erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy AT raymondckchan erpstudyonproactiveandreactiveresponseinhibitioninindividualswithschizotypy
_version_	1718378797149978624

An ERP study on proactive and reactive response inhibition in individuals with schizotypy

Ejemplares similares