The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.

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Autores principales:	Seweryn Mroczek, Justyna Chlebowska, Tomasz M. Kuliński, Olga Gewartowska, Jakub Gruchota, Dominik Cysewski, Vladyslava Liudkovska, Ewa Borsuk, Dominika Nowis, Andrzej Dziembowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2729a3c633ac4d3d9be13d21bf41dfa0
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spelling	oai:doaj.org-article:2729a3c633ac4d3d9be13d21bf41dfa02021-12-02T14:40:22ZThe non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma10.1038/s41467-017-00578-52041-1723https://doaj.org/article/2729a3c633ac4d3d9be13d21bf41dfa02017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00578-5https://doaj.org/toc/2041-1723FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.Seweryn MroczekJustyna ChlebowskaTomasz M. KulińskiOlga GewartowskaJakub GruchotaDominik CysewskiVladyslava LiudkovskaEwa BorsukDominika NowisAndrzej DziembowskiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seweryn Mroczek Justyna Chlebowska Tomasz M. Kuliński Olga Gewartowska Jakub Gruchota Dominik Cysewski Vladyslava Liudkovska Ewa Borsuk Dominika Nowis Andrzej Dziembowski The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
description	FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.
format	article
author	Seweryn Mroczek Justyna Chlebowska Tomasz M. Kuliński Olga Gewartowska Jakub Gruchota Dominik Cysewski Vladyslava Liudkovska Ewa Borsuk Dominika Nowis Andrzej Dziembowski
author_facet	Seweryn Mroczek Justyna Chlebowska Tomasz M. Kuliński Olga Gewartowska Jakub Gruchota Dominik Cysewski Vladyslava Liudkovska Ewa Borsuk Dominika Nowis Andrzej Dziembowski
author_sort	Seweryn Mroczek
title	The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
title_short	The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
title_full	The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
title_fullStr	The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
title_full_unstemmed	The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
title_sort	non-canonical poly(a) polymerase fam46c acts as an onco-suppressor in multiple myeloma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2729a3c633ac4d3d9be13d21bf41dfa0
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The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

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