Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum

This study investigated the variation in oligosaccharide levels in the breast milk of south Chinese mothers in a prolonged breastfeeding period of up to 400 days postpartum. A total of 488 breast milk samples were collected from 335 healthy mothers at five different time points: 0–5 days, 10–15 days...

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Autores principales:	Shuang Liu, Xiaokun Cai, Jin Wang, Yingyi Mao, Yan Zou, Fang Tian, Bo Peng, Jiaqiang Hu, Yanrong Zhao, Shuo Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast milk human milk oligosaccharides lactational stages variation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/2729ca734b7d4176b7a557eb2a77f652
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spelling	oai:doaj.org-article:2729ca734b7d4176b7a557eb2a77f6522021-11-25T18:36:08ZSix Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum10.3390/nu131140172072-6643https://doaj.org/article/2729ca734b7d4176b7a557eb2a77f6522021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4017https://doaj.org/toc/2072-6643This study investigated the variation in oligosaccharide levels in the breast milk of south Chinese mothers in a prolonged breastfeeding period of up to 400 days postpartum. A total of 488 breast milk samples were collected from 335 healthy mothers at five different time points: 0–5 days, 10–15 days, 40–45 days, 200–240 days, and 300–400 days postpartum. A high-performance anion-exchange chromatography-pulsed amperometric detector (HPAEC-PAD) was used to quantify 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL). In this study, we found six oligosaccharides that were present in breast milk from 0 to 400 days postpartum. The median value ranges of individual oligosaccharide components in this study were 1013–2891 mg/L 2′-FL, 193–1421 mg/L 3-FL, 314–1478 mg/L LNT, 44–255 mg/L LNnT, 111–241 mg/L 3′-SL, and 23–602 mg/L6′-SL. HMO levels decreased over the lactation periods, except for 3-FL, which increased throughout lactation. The predominant fucosylated and sialylated HMOs were 2′-FL and 6′-SL at 40–45 days postpartum and changed to 3-FL and 3′-SL at 200–240 days postpartum. Results from this study showed that lactating women continue to provide their offspring with a high level of 2′-FL one year after delivery, suggesting that 2′-FL may play an important role for infants in early life. Our findings also provide further evidence in support of breastfeeding after one-year postpartum.Shuang LiuXiaokun CaiJin WangYingyi MaoYan ZouFang TianBo PengJiaqiang HuYanrong ZhaoShuo WangMDPI AGarticlebreast milkhuman milk oligosaccharideslactational stagesvariationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4017, p 4017 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast milk human milk oligosaccharides lactational stages variation Nutrition. Foods and food supply TX341-641
spellingShingle	breast milk human milk oligosaccharides lactational stages variation Nutrition. Foods and food supply TX341-641 Shuang Liu Xiaokun Cai Jin Wang Yingyi Mao Yan Zou Fang Tian Bo Peng Jiaqiang Hu Yanrong Zhao Shuo Wang Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
description	This study investigated the variation in oligosaccharide levels in the breast milk of south Chinese mothers in a prolonged breastfeeding period of up to 400 days postpartum. A total of 488 breast milk samples were collected from 335 healthy mothers at five different time points: 0–5 days, 10–15 days, 40–45 days, 200–240 days, and 300–400 days postpartum. A high-performance anion-exchange chromatography-pulsed amperometric detector (HPAEC-PAD) was used to quantify 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL). In this study, we found six oligosaccharides that were present in breast milk from 0 to 400 days postpartum. The median value ranges of individual oligosaccharide components in this study were 1013–2891 mg/L 2′-FL, 193–1421 mg/L 3-FL, 314–1478 mg/L LNT, 44–255 mg/L LNnT, 111–241 mg/L 3′-SL, and 23–602 mg/L6′-SL. HMO levels decreased over the lactation periods, except for 3-FL, which increased throughout lactation. The predominant fucosylated and sialylated HMOs were 2′-FL and 6′-SL at 40–45 days postpartum and changed to 3-FL and 3′-SL at 200–240 days postpartum. Results from this study showed that lactating women continue to provide their offspring with a high level of 2′-FL one year after delivery, suggesting that 2′-FL may play an important role for infants in early life. Our findings also provide further evidence in support of breastfeeding after one-year postpartum.
format	article
author	Shuang Liu Xiaokun Cai Jin Wang Yingyi Mao Yan Zou Fang Tian Bo Peng Jiaqiang Hu Yanrong Zhao Shuo Wang
author_facet	Shuang Liu Xiaokun Cai Jin Wang Yingyi Mao Yan Zou Fang Tian Bo Peng Jiaqiang Hu Yanrong Zhao Shuo Wang
author_sort	Shuang Liu
title	Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
title_short	Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
title_full	Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
title_fullStr	Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
title_full_unstemmed	Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum
title_sort	six oligosaccharides’ variation in breast milk: a study in south china from 0 to 400 days postpartum
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2729ca734b7d4176b7a557eb2a77f652
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Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum

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