A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regu...

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Autores principales: Xuexin Zhang, Trayambak Pathak, Ryan Yoast, Scott Emrich, Ping Xin, Robert M. Nwokonko, Martin Johnson, Shilan Wu, Céline Delierneux, Maxime Gueguinou, Nadine Hempel, James W. Putney, Donald L. Gill, Mohamed Trebak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/273145bab6b34b6fac4674fdd0ecc38c
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spelling oai:doaj.org-article:273145bab6b34b6fac4674fdd0ecc38c2021-12-02T15:35:04ZA calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction10.1038/s41467-019-09593-02041-1723https://doaj.org/article/273145bab6b34b6fac4674fdd0ecc38c2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09593-0https://doaj.org/toc/2041-1723ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.Xuexin ZhangTrayambak PathakRyan YoastScott EmrichPing XinRobert M. NwokonkoMartin JohnsonShilan WuCéline DelierneuxMaxime GueguinouNadine HempelJames W. PutneyDonald L. GillMohamed TrebakNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
description ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.
format article
author Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
author_facet Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
author_sort Xuexin Zhang
title A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_short A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_full A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_fullStr A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_full_unstemmed A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_sort calcium/camp signaling loop at the orai1 mouth drives channel inactivation to shape nfat induction
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/273145bab6b34b6fac4674fdd0ecc38c
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