Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease

Yuki Abe,1 Masaru Suzuki,1 Hiroshi Shima,2 Yusuke Shiraishi,2 Naoya Tanabe,2 Susumu Sato,2 Kaoruko Shimizu,1 Hirokazu Kimura,1 Hironi Makita,1,3 Toyohiro Hirai,2 Satoshi Konno,1 Masaharu Nishimura1,3 1Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido U...

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Autores principales:	Abe Y, Suzuki M, Shima H, Shiraishi Y, Tanabe N, Sato S, Shimizu K, Kimura H, Makita H, Hirai T, Konno S, Nishimura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	annual body weight change body mass index chronic obstructive pulmonary disease mortality prognosis weight loss Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/2733663f13bb4fcbab7259dc607b6ded
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spelling	oai:doaj.org-article:2733663f13bb4fcbab7259dc607b6ded2021-11-30T18:50:37ZAnnual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease1178-2005https://doaj.org/article/2733663f13bb4fcbab7259dc607b6ded2021-11-01T00:00:00Zhttps://www.dovepress.com/annual-body-weight-change-and-prognosis-in-chronic-obstructive-pulmona-peer-reviewed-fulltext-article-COPDhttps://doaj.org/toc/1178-2005Yuki Abe,1 Masaru Suzuki,1 Hiroshi Shima,2 Yusuke Shiraishi,2 Naoya Tanabe,2 Susumu Sato,2 Kaoruko Shimizu,1 Hirokazu Kimura,1 Hironi Makita,1,3 Toyohiro Hirai,2 Satoshi Konno,1 Masaharu Nishimura1,3 1Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, 060-8638, Japan; 2Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan; 3Hokkaido Medical Research Institute for Respiratory Diseases, Chuo-ku, Sapporo, 060-0063, JapanCorrespondence: Masaru SuzukiDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, JapanTel +81-11-706-5911Fax +81-11-706-7899Email suzumasa@med.hokudai.ac.jpPurpose: Low body mass index (BMI) has been reported to be associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). In contrast, a detailed analysis of the association between body weight change over time and prognosis is not sufficient, particularly in Japanese patients with COPD who have been reported to be much thinner compared to Westerners. This study aimed to investigate the relationship between annual body weight change and long-term prognosis in Japanese patients with COPD in two independent cohorts.Patients and Methods: We analyzed 279 patients with COPD who participated in the Hokkaido COPD cohort study as a discovery cohort. We divided participants into three groups according to quartiles of annual body weight change calculated by the data from the first 5 years: weight loss group ( 0.20 kg/year). The association between annual body weight change and prognosis was replicated in the Kyoto University cohort (n = 247).Results: In the Hokkaido COPD cohort study, the weight loss group had significantly worse mortality than the other groups, whereas there was no difference in BMI at baseline. In the multivariate analysis, annual body weight change was an independent risk factor for all-cause mortality, which was confirmed in the Kyoto University cohort.Conclusion: Annual body weight loss is associated with poor prognosis in Japanese patients with COPD, independent of baseline BMI. Longitudinal assessment of body weight is important for the management of COPD.Keywords: annual body weight change, body mass index, chronic obstructive pulmonary disease, mortality, prognosis, weight lossAbe YSuzuki MShima HShiraishi YTanabe NSato SShimizu KKimura HMakita HHirai TKonno SNishimura MDove Medical Pressarticleannual body weight changebody mass indexchronic obstructive pulmonary diseasemortalityprognosisweight lossDiseases of the respiratory systemRC705-779ENInternational Journal of COPD, Vol Volume 16, Pp 3243-3253 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	annual body weight change body mass index chronic obstructive pulmonary disease mortality prognosis weight loss Diseases of the respiratory system RC705-779
spellingShingle	annual body weight change body mass index chronic obstructive pulmonary disease mortality prognosis weight loss Diseases of the respiratory system RC705-779 Abe Y Suzuki M Shima H Shiraishi Y Tanabe N Sato S Shimizu K Kimura H Makita H Hirai T Konno S Nishimura M Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
description	Yuki Abe,1 Masaru Suzuki,1 Hiroshi Shima,2 Yusuke Shiraishi,2 Naoya Tanabe,2 Susumu Sato,2 Kaoruko Shimizu,1 Hirokazu Kimura,1 Hironi Makita,1,3 Toyohiro Hirai,2 Satoshi Konno,1 Masaharu Nishimura1,3 1Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, 060-8638, Japan; 2Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan; 3Hokkaido Medical Research Institute for Respiratory Diseases, Chuo-ku, Sapporo, 060-0063, JapanCorrespondence: Masaru SuzukiDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, JapanTel +81-11-706-5911Fax +81-11-706-7899Email suzumasa@med.hokudai.ac.jpPurpose: Low body mass index (BMI) has been reported to be associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). In contrast, a detailed analysis of the association between body weight change over time and prognosis is not sufficient, particularly in Japanese patients with COPD who have been reported to be much thinner compared to Westerners. This study aimed to investigate the relationship between annual body weight change and long-term prognosis in Japanese patients with COPD in two independent cohorts.Patients and Methods: We analyzed 279 patients with COPD who participated in the Hokkaido COPD cohort study as a discovery cohort. We divided participants into three groups according to quartiles of annual body weight change calculated by the data from the first 5 years: weight loss group ( 0.20 kg/year). The association between annual body weight change and prognosis was replicated in the Kyoto University cohort (n = 247).Results: In the Hokkaido COPD cohort study, the weight loss group had significantly worse mortality than the other groups, whereas there was no difference in BMI at baseline. In the multivariate analysis, annual body weight change was an independent risk factor for all-cause mortality, which was confirmed in the Kyoto University cohort.Conclusion: Annual body weight loss is associated with poor prognosis in Japanese patients with COPD, independent of baseline BMI. Longitudinal assessment of body weight is important for the management of COPD.Keywords: annual body weight change, body mass index, chronic obstructive pulmonary disease, mortality, prognosis, weight loss
format	article
author	Abe Y Suzuki M Shima H Shiraishi Y Tanabe N Sato S Shimizu K Kimura H Makita H Hirai T Konno S Nishimura M
author_facet	Abe Y Suzuki M Shima H Shiraishi Y Tanabe N Sato S Shimizu K Kimura H Makita H Hirai T Konno S Nishimura M
author_sort	Abe Y
title	Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
title_short	Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
title_full	Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
title_fullStr	Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
title_sort	annual body weight change and prognosis in chronic obstructive pulmonary disease
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2733663f13bb4fcbab7259dc607b6ded
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Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease

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