Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance

6-phosphogluconate dehydrogenase is commonly upregulated in cancers. Here, the authors show that activation of EGFR induces phosphorylation of this enzyme at Y481 to activate the pentose phosphate pathway, which consequently reduces ROS and accelerates DNA synthesis to promote tumor growth and radio...

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Autores principales: Ruilong Liu, Wenfeng Li, Bangbao Tao, Xiongjun Wang, Zhuo Yang, Yajuan Zhang, Chenyao Wang, Rongzhi Liu, Hong Gao, Ji Liang, Weiwei Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/27367c897216489d8920121d5f855b5a
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spelling oai:doaj.org-article:27367c897216489d8920121d5f855b5a2021-12-02T17:02:01ZTyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance10.1038/s41467-019-08921-82041-1723https://doaj.org/article/27367c897216489d8920121d5f855b5a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08921-8https://doaj.org/toc/2041-17236-phosphogluconate dehydrogenase is commonly upregulated in cancers. Here, the authors show that activation of EGFR induces phosphorylation of this enzyme at Y481 to activate the pentose phosphate pathway, which consequently reduces ROS and accelerates DNA synthesis to promote tumor growth and radioresistance.Ruilong LiuWenfeng LiBangbao TaoXiongjun WangZhuo YangYajuan ZhangChenyao WangRongzhi LiuHong GaoJi LiangWeiwei YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ruilong Liu
Wenfeng Li
Bangbao Tao
Xiongjun Wang
Zhuo Yang
Yajuan Zhang
Chenyao Wang
Rongzhi Liu
Hong Gao
Ji Liang
Weiwei Yang
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
description 6-phosphogluconate dehydrogenase is commonly upregulated in cancers. Here, the authors show that activation of EGFR induces phosphorylation of this enzyme at Y481 to activate the pentose phosphate pathway, which consequently reduces ROS and accelerates DNA synthesis to promote tumor growth and radioresistance.
format article
author Ruilong Liu
Wenfeng Li
Bangbao Tao
Xiongjun Wang
Zhuo Yang
Yajuan Zhang
Chenyao Wang
Rongzhi Liu
Hong Gao
Ji Liang
Weiwei Yang
author_facet Ruilong Liu
Wenfeng Li
Bangbao Tao
Xiongjun Wang
Zhuo Yang
Yajuan Zhang
Chenyao Wang
Rongzhi Liu
Hong Gao
Ji Liang
Weiwei Yang
author_sort Ruilong Liu
title Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
title_short Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
title_full Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
title_fullStr Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
title_full_unstemmed Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
title_sort tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/27367c897216489d8920121d5f855b5a
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AT wenfengli tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT bangbaotao tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT xiongjunwang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT zhuoyang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT yajuanzhang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT chenyaowang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT rongzhiliu tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT honggao tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT jiliang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
AT weiweiyang tyrosinephosphorylationactivates6phosphogluconatedehydrogenaseandpromotestumorgrowthandradiationresistance
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