Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated mineralization and brittle bone.

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Autores principales:	Christina Vrahnas, Martha Blank, Toby A. Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Huynh Nguyen, Mark R. Forwood, Yifang Hu, Mika Ikegame, Keith R. Bambery, Cyril Petibois, Eleanor J. Mackie, Mark J. Tobin, Gordon K. Smyth, Jonathan S. Oakhill, T. John Martin, Natalie A. Sims
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2738dceae2514fd1ae0b6fb54d703a48
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spelling	oai:doaj.org-article:2738dceae2514fd1ae0b6fb54d703a482021-12-02T16:57:22ZIncreased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone10.1038/s41467-019-11373-92041-1723https://doaj.org/article/2738dceae2514fd1ae0b6fb54d703a482019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11373-9https://doaj.org/toc/2041-1723Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated mineralization and brittle bone.Christina VrahnasMartha BlankToby A. DiteLiliana TatarczuchNiloufar AnsariBlessing Crimeen-IrwinHuynh NguyenMark R. ForwoodYifang HuMika IkegameKeith R. BamberyCyril PetiboisEleanor J. MackieMark J. TobinGordon K. SmythJonathan S. OakhillT. John MartinNatalie A. SimsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina Vrahnas Martha Blank Toby A. Dite Liliana Tatarczuch Niloufar Ansari Blessing Crimeen-Irwin Huynh Nguyen Mark R. Forwood Yifang Hu Mika Ikegame Keith R. Bambery Cyril Petibois Eleanor J. Mackie Mark J. Tobin Gordon K. Smyth Jonathan S. Oakhill T. John Martin Natalie A. Sims Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
description	Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated mineralization and brittle bone.
format	article
author	Christina Vrahnas Martha Blank Toby A. Dite Liliana Tatarczuch Niloufar Ansari Blessing Crimeen-Irwin Huynh Nguyen Mark R. Forwood Yifang Hu Mika Ikegame Keith R. Bambery Cyril Petibois Eleanor J. Mackie Mark J. Tobin Gordon K. Smyth Jonathan S. Oakhill T. John Martin Natalie A. Sims
author_facet	Christina Vrahnas Martha Blank Toby A. Dite Liliana Tatarczuch Niloufar Ansari Blessing Crimeen-Irwin Huynh Nguyen Mark R. Forwood Yifang Hu Mika Ikegame Keith R. Bambery Cyril Petibois Eleanor J. Mackie Mark J. Tobin Gordon K. Smyth Jonathan S. Oakhill T. John Martin Natalie A. Sims
author_sort	Christina Vrahnas
title	Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
title_short	Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
title_full	Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
title_fullStr	Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
title_full_unstemmed	Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
title_sort	increased autophagy in ephrinb2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2738dceae2514fd1ae0b6fb54d703a48
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Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

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