Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Lan Zhan...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Acceso en línea: | https://doaj.org/article/27394dbd7b47429da7559893462da614 |
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| Sumario: | He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Lan ZhangDepartment of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, 200032, People’s Republic of ChinaTel +86-021-64041990Fax +86 021-64038472Email zhang.lan@zs-hospital.sh.cnPurpose: Ribosomal protein metallopanstimulin-1 (MPS-1) is implicated in tumorigenesis. However, to date, the underlying role of MPS-1 in the generation, progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. This study aims to investigate the expression of MPS-1 in HCC and its significance for the prognosis of HCC.Methods: The Oncomine and GEPIA databases were used to analyze the expression pattern of MPS-1 in HCC. Immunohistochemical staining was performed on tissue microarrays containing 169 HCC tissue samples to examine the expression of MPS-1. In addition, univariate and multivariate Cox regression analyses and Kaplan–Meier analysis were used to verify the correlation between clinicopathological factors in HCC patients and its clinical prognostic significance.Results: MPS-1 was more highly expressed in HCC than in normal tissues, and MPS-1 expression was correlated with serum AFP levels (P = 0.003), liver cirrhosis (P = 0.024), tumor embolus (P = 0.009) and tumor recurrence (P < 0.003). MPS-1 was an independent prognostic factor for the overall survival of HCC (HR, 1.92; 95% CI, 1.01– 3.68), and a higher expression of MPS-1 predicted poorer survival. Furthermore, high expression of MPS-1 indicated a poor prognosis in patients with AFP positivity, cirrhosis or HBsAg positivity.Conclusion: These findings demonstrate that MPS-1 is highly expressed in HCC and serves as an independent prognostic marker, highlighting the potential role of MPS-1 as a novel biomarker and therapeutic target for HCC.Keywords: hepatocellular carcinoma, ribosomal protein, MPS-1, biomarker, prognosis |
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