Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma

He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Lan Zhan...

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Autores principales:	Jiang H, Yuan F, Zhao Z, Xue T, Ge N, Ren Z, Zhang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hepatocellular carcinoma ribosomal protein mps-1 biomarker prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/27394dbd7b47429da7559893462da614
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spelling	oai:doaj.org-article:27394dbd7b47429da7559893462da6142021-11-30T18:50:36ZExpression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma1178-7074https://doaj.org/article/27394dbd7b47429da7559893462da6142021-12-01T00:00:00Zhttps://www.dovepress.com/expression-and-clinical-significance-of-mps-1-in-hepatocellular-carcin-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Lan ZhangDepartment of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, 200032, People’s Republic of ChinaTel +86-021-64041990Fax +86 021-64038472Email zhang.lan@zs-hospital.sh.cnPurpose: Ribosomal protein metallopanstimulin-1 (MPS-1) is implicated in tumorigenesis. However, to date, the underlying role of MPS-1 in the generation, progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. This study aims to investigate the expression of MPS-1 in HCC and its significance for the prognosis of HCC.Methods: The Oncomine and GEPIA databases were used to analyze the expression pattern of MPS-1 in HCC. Immunohistochemical staining was performed on tissue microarrays containing 169 HCC tissue samples to examine the expression of MPS-1. In addition, univariate and multivariate Cox regression analyses and Kaplan–Meier analysis were used to verify the correlation between clinicopathological factors in HCC patients and its clinical prognostic significance.Results: MPS-1 was more highly expressed in HCC than in normal tissues, and MPS-1 expression was correlated with serum AFP levels (P = 0.003), liver cirrhosis (P = 0.024), tumor embolus (P = 0.009) and tumor recurrence (P < 0.003). MPS-1 was an independent prognostic factor for the overall survival of HCC (HR, 1.92; 95% CI, 1.01– 3.68), and a higher expression of MPS-1 predicted poorer survival. Furthermore, high expression of MPS-1 indicated a poor prognosis in patients with AFP positivity, cirrhosis or HBsAg positivity.Conclusion: These findings demonstrate that MPS-1 is highly expressed in HCC and serves as an independent prognostic marker, highlighting the potential role of MPS-1 as a novel biomarker and therapeutic target for HCC.Keywords: hepatocellular carcinoma, ribosomal protein, MPS-1, biomarker, prognosisJiang HYuan FZhao ZXue TGe NRen ZZhang LDove Medical Pressarticlehepatocellular carcinomaribosomal proteinmps-1biomarkerprognosisMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9145-9152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma ribosomal protein mps-1 biomarker prognosis Medicine (General) R5-920
spellingShingle	hepatocellular carcinoma ribosomal protein mps-1 biomarker prognosis Medicine (General) R5-920 Jiang H Yuan F Zhao Z Xue T Ge N Ren Z Zhang L Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
description	He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Lan ZhangDepartment of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, 200032, People’s Republic of ChinaTel +86-021-64041990Fax +86 021-64038472Email zhang.lan@zs-hospital.sh.cnPurpose: Ribosomal protein metallopanstimulin-1 (MPS-1) is implicated in tumorigenesis. However, to date, the underlying role of MPS-1 in the generation, progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. This study aims to investigate the expression of MPS-1 in HCC and its significance for the prognosis of HCC.Methods: The Oncomine and GEPIA databases were used to analyze the expression pattern of MPS-1 in HCC. Immunohistochemical staining was performed on tissue microarrays containing 169 HCC tissue samples to examine the expression of MPS-1. In addition, univariate and multivariate Cox regression analyses and Kaplan–Meier analysis were used to verify the correlation between clinicopathological factors in HCC patients and its clinical prognostic significance.Results: MPS-1 was more highly expressed in HCC than in normal tissues, and MPS-1 expression was correlated with serum AFP levels (P = 0.003), liver cirrhosis (P = 0.024), tumor embolus (P = 0.009) and tumor recurrence (P < 0.003). MPS-1 was an independent prognostic factor for the overall survival of HCC (HR, 1.92; 95% CI, 1.01– 3.68), and a higher expression of MPS-1 predicted poorer survival. Furthermore, high expression of MPS-1 indicated a poor prognosis in patients with AFP positivity, cirrhosis or HBsAg positivity.Conclusion: These findings demonstrate that MPS-1 is highly expressed in HCC and serves as an independent prognostic marker, highlighting the potential role of MPS-1 as a novel biomarker and therapeutic target for HCC.Keywords: hepatocellular carcinoma, ribosomal protein, MPS-1, biomarker, prognosis
format	article
author	Jiang H Yuan F Zhao Z Xue T Ge N Ren Z Zhang L
author_facet	Jiang H Yuan F Zhao Z Xue T Ge N Ren Z Zhang L
author_sort	Jiang H
title	Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
title_short	Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
title_full	Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
title_fullStr	Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
title_full_unstemmed	Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
title_sort	expression and clinical significance of mps-1 in hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/27394dbd7b47429da7559893462da614
work_keys_str_mv	AT jiangh expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT yuanf expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT zhaoz expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT xuet expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT gen expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT renz expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma AT zhangl expressionandclinicalsignificanceofmps1inhepatocellularcarcinoma
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Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma

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