Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis

Abstract Schizophrenia is a severe mental disorder and one of its characteristics is cognitive impairments. Findings regarding levels of the heme metabolite and plasma antioxidant bilirubin in schizophrenia are inconclusive. However, a recently published study indicate that low levels of bilirubin m...

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Autores principales:	Meneca Becklén, Funda Orhan, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Lena Flyckt, Sophie Erhardt, Helena Fatouros-Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/273a69538d4f456db2732a08c43ed868
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spelling	oai:doaj.org-article:273a69538d4f456db2732a08c43ed8682021-12-02T18:15:33ZPlasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis10.1038/s41598-021-87096-z2045-2322https://doaj.org/article/273a69538d4f456db2732a08c43ed8682021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87096-zhttps://doaj.org/toc/2045-2322Abstract Schizophrenia is a severe mental disorder and one of its characteristics is cognitive impairments. Findings regarding levels of the heme metabolite and plasma antioxidant bilirubin in schizophrenia are inconclusive. However, a recently published study indicate that low levels of bilirubin may be implicated in the memory impairments seen in the disorder. The aim of this cross-sectional study was to investigate the levels of bilirubin in individuals with a first-episode psychosis (FEP) and to examine if bilirubin levels were associated to cognitive impairments, symptoms and duration of untreated psychosis (DUP). Bilirubin levels were reduced in 39 individuals with FEP compared with 20 HC (median [IQR]: 11.0 [9.0–13.0] µM vs. 15.0 [11.5–18.5] µM). In individuals with FEP, bilirubin levels were also positively correlated to two working memory tests (r = 0.40 and r = 0.32) and inversely correlated to DUP (r = − 0.36). Findings were not influenced by confounding factors. The results confirm the antioxidant deficit previously seen in schizophrenia, but also indicate that these changes may be related to DUP. The study also confirms that bilirubin may be implicated in the cognitive deficits that accompanies the disorder, here for the first time presented in individuals with FEP.Meneca BecklénFunda OrhanFredrik PiehlSimon CervenkaCarl M. SellgrenLena FlycktSophie ErhardtHelena Fatouros-BergmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meneca Becklén Funda Orhan Fredrik Piehl Simon Cervenka Carl M. Sellgren Lena Flyckt Sophie Erhardt Helena Fatouros-Bergman Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
description	Abstract Schizophrenia is a severe mental disorder and one of its characteristics is cognitive impairments. Findings regarding levels of the heme metabolite and plasma antioxidant bilirubin in schizophrenia are inconclusive. However, a recently published study indicate that low levels of bilirubin may be implicated in the memory impairments seen in the disorder. The aim of this cross-sectional study was to investigate the levels of bilirubin in individuals with a first-episode psychosis (FEP) and to examine if bilirubin levels were associated to cognitive impairments, symptoms and duration of untreated psychosis (DUP). Bilirubin levels were reduced in 39 individuals with FEP compared with 20 HC (median [IQR]: 11.0 [9.0–13.0] µM vs. 15.0 [11.5–18.5] µM). In individuals with FEP, bilirubin levels were also positively correlated to two working memory tests (r = 0.40 and r = 0.32) and inversely correlated to DUP (r = − 0.36). Findings were not influenced by confounding factors. The results confirm the antioxidant deficit previously seen in schizophrenia, but also indicate that these changes may be related to DUP. The study also confirms that bilirubin may be implicated in the cognitive deficits that accompanies the disorder, here for the first time presented in individuals with FEP.
format	article
author	Meneca Becklén Funda Orhan Fredrik Piehl Simon Cervenka Carl M. Sellgren Lena Flyckt Sophie Erhardt Helena Fatouros-Bergman
author_facet	Meneca Becklén Funda Orhan Fredrik Piehl Simon Cervenka Carl M. Sellgren Lena Flyckt Sophie Erhardt Helena Fatouros-Bergman
author_sort	Meneca Becklén
title	Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
title_short	Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
title_full	Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
title_fullStr	Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
title_full_unstemmed	Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
title_sort	plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/273a69538d4f456db2732a08c43ed868
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Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis

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