Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19

Background: Diabetics exhibit elevated serum ferritin level when compared to non-diabetic counterpart, indicates impact of its association with coronavirus disease 2019 (COVID-19) infection and disease progression. Ferritin is a key mediator of immune dysregulation through direct immunosuppression c...

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Autores principales:	Mukesh Kumar, CM Bindu, AC Shyam, R Reena
Formato:	article
Lenguaje:	EN
Publicado:	Manipal College of Medical Sciences, Pokhara 2021
Materias:	type 2 diabetes mellitus hba1c serum ferritin severe acute respiratory syndrome coronavirus-2 Medicine R
Acceso en línea:	https://doi.org/10.3126/ajms.v12i12.39717 https://doaj.org/article/273bf92373bc4a1d862c0f6eddd27bfc
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spelling	oai:doaj.org-article:273bf92373bc4a1d862c0f6eddd27bfc2021-12-01T11:43:52ZFerritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19https://doi.org/10.3126/ajms.v12i12.397172467-91002091-0576https://doaj.org/article/273bf92373bc4a1d862c0f6eddd27bfc2021-12-01T00:00:00Zhttps://www.nepjol.info/index.php/AJMS/article/view/39717https://doaj.org/toc/2467-9100https://doaj.org/toc/2091-0576Background: Diabetics exhibit elevated serum ferritin level when compared to non-diabetic counterpart, indicates impact of its association with coronavirus disease 2019 (COVID-19) infection and disease progression. Ferritin is a key mediator of immune dysregulation through direct immunosuppression contributing to cytokine storm resulting in fatal outcome in COVID-19. Aims and Objectives: This study aims to estimate serum ferritin in diabetic (cases) and non-diabetic (controls) COVID-19 patients and its correlation with their diabetic profile (FBS, PPBS, RBS, and HbA1C). Materials and Methods: A retrospective case–control study conducted at Rajarajeswari Medical College and Hospital, Bengaluru, for a period of 8 months among diabetic and non-diabetic COVID-19 patients. Results: The study population consisted of 957 individuals, out of them, 425 patients were type 2 diabetes mellitus and 532 were non-diabetic COVID-19-positive patients (controls). Diabetic profile parameters (FBS, PPBS, RBS, and HbA1c) and serum ferritin were significantly (P<0.05) high in cases as compared to controls. Among diabetic COVID-19, the glycated hemoglobin and serum ferritin showed a significantly positive correlation (r=0.55) with serum ferritin (mean=648.98±320.48). Conclusion: Hyperferritinemia is more prevalent in diabetic COVID-19 individuals. Serum ferritin can be considered as a valuable biomarker to screen the diabetic and non-diabetic for the presence of hyperinflammation and to predict severity of COVID-19 infection so that it will help the clinician for proper management.Mukesh Kumar CM Bindu AC Shyam R Reena Manipal College of Medical Sciences, Pokharaarticletype 2 diabetes mellitushba1cserum ferritinsevere acute respiratory syndrome coronavirus-2MedicineRENAsian Journal of Medical Sciences, Vol 12, Iss 12, Pp 23-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus hba1c serum ferritin severe acute respiratory syndrome coronavirus-2 Medicine R
spellingShingle	type 2 diabetes mellitus hba1c serum ferritin severe acute respiratory syndrome coronavirus-2 Medicine R Mukesh Kumar CM Bindu AC Shyam R Reena Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
description	Background: Diabetics exhibit elevated serum ferritin level when compared to non-diabetic counterpart, indicates impact of its association with coronavirus disease 2019 (COVID-19) infection and disease progression. Ferritin is a key mediator of immune dysregulation through direct immunosuppression contributing to cytokine storm resulting in fatal outcome in COVID-19. Aims and Objectives: This study aims to estimate serum ferritin in diabetic (cases) and non-diabetic (controls) COVID-19 patients and its correlation with their diabetic profile (FBS, PPBS, RBS, and HbA1C). Materials and Methods: A retrospective case–control study conducted at Rajarajeswari Medical College and Hospital, Bengaluru, for a period of 8 months among diabetic and non-diabetic COVID-19 patients. Results: The study population consisted of 957 individuals, out of them, 425 patients were type 2 diabetes mellitus and 532 were non-diabetic COVID-19-positive patients (controls). Diabetic profile parameters (FBS, PPBS, RBS, and HbA1c) and serum ferritin were significantly (P<0.05) high in cases as compared to controls. Among diabetic COVID-19, the glycated hemoglobin and serum ferritin showed a significantly positive correlation (r=0.55) with serum ferritin (mean=648.98±320.48). Conclusion: Hyperferritinemia is more prevalent in diabetic COVID-19 individuals. Serum ferritin can be considered as a valuable biomarker to screen the diabetic and non-diabetic for the presence of hyperinflammation and to predict severity of COVID-19 infection so that it will help the clinician for proper management.
format	article
author	Mukesh Kumar CM Bindu AC Shyam R Reena
author_facet	Mukesh Kumar CM Bindu AC Shyam R Reena
author_sort	Mukesh Kumar
title	Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
title_short	Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
title_full	Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
title_fullStr	Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
title_full_unstemmed	Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19
title_sort	ferritin – the key model inflammatory marker in diabetic and non-diabetic covid-19
publisher	Manipal College of Medical Sciences, Pokhara
publishDate	2021
url	https://doi.org/10.3126/ajms.v12i12.39717 https://doaj.org/article/273bf92373bc4a1d862c0f6eddd27bfc
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Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19

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