Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

Abstract Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they...

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Autores principales:	Michele Celestino, Valeria Balmaceda Valdez, Paola Brun, Ignazio Castagliuolo, Carla Mucignat-Caretta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/273d62a0217e4a13b662cbf223fe7999
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spelling	oai:doaj.org-article:273d62a0217e4a13b662cbf223fe79992021-12-02T14:12:08ZDifferential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice10.1038/s41598-020-80048-z2045-2322https://doaj.org/article/273d62a0217e4a13b662cbf223fe79992021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80048-zhttps://doaj.org/toc/2045-2322Abstract Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.Michele CelestinoValeria Balmaceda ValdezPaola BrunIgnazio CastagliuoloCarla Mucignat-CarettaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michele Celestino Valeria Balmaceda Valdez Paola Brun Ignazio Castagliuolo Carla Mucignat-Caretta Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
description	Abstract Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.
format	article
author	Michele Celestino Valeria Balmaceda Valdez Paola Brun Ignazio Castagliuolo Carla Mucignat-Caretta
author_facet	Michele Celestino Valeria Balmaceda Valdez Paola Brun Ignazio Castagliuolo Carla Mucignat-Caretta
author_sort	Michele Celestino
title	Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
title_short	Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
title_full	Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
title_fullStr	Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
title_full_unstemmed	Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
title_sort	differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/273d62a0217e4a13b662cbf223fe7999
work_keys_str_mv	AT michelecelestino differentialeffectsofsodiumchlorideandmonosodiumglutamateonkidneyofadultandagingmice AT valeriabalmacedavaldez differentialeffectsofsodiumchlorideandmonosodiumglutamateonkidneyofadultandagingmice AT paolabrun differentialeffectsofsodiumchlorideandmonosodiumglutamateonkidneyofadultandagingmice AT ignaziocastagliuolo differentialeffectsofsodiumchlorideandmonosodiumglutamateonkidneyofadultandagingmice AT carlamucignatcaretta differentialeffectsofsodiumchlorideandmonosodiumglutamateonkidneyofadultandagingmice
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Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

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