A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid
Considering the vital physiological functions of dopamine (DA) and uric acid (UA) and their coexistence in the biological matrix, the development of biosensing techniques for their simultaneous and sensitive detection is highly desirable for diagnostic and analytical applications. Therefore, Ti<s...
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2021
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oai:doaj.org-article:273ebcafb50642cd843af307ac51ced22021-11-25T16:55:45ZA Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid10.3390/bios111104622079-6374https://doaj.org/article/273ebcafb50642cd843af307ac51ced22021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/462https://doaj.org/toc/2079-6374Considering the vital physiological functions of dopamine (DA) and uric acid (UA) and their coexistence in the biological matrix, the development of biosensing techniques for their simultaneous and sensitive detection is highly desirable for diagnostic and analytical applications. Therefore, Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO heterostructure with a double-deck layer was fabricated through electrochemical reduction. The rGO was modified on a porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> electrode as the biosensor for the detection of DA and UA simultaneously. Debye length was regulated by the alteration of rGO mass on the surface of the Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> electrode. Debye length decreased with respect to the rGO electrode modified with further rGO mass, indicating that fewer DA molecules were capable of surpassing the equilibrium double layer and reaching the surface of rGO to achieve the voltammetric response of DA. Thus, the proposed Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO sensor presented an excellent performance in detecting DA and UA with a wide linear range of 0.1–100 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M and 1–1000 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M and a low detection limit of 9.5 nM and 0.3 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M, respectively. Additionally, the proposed Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO electrode displayed good repeatability, selectivity, and proved to be available for real sample analysis.Yangguang ZhuQichen TianXiufen LiLidong WuAimin YuGuosong LaiLi FuQiuping WeiDan DaiNan JiangHe LiChen YeCheng-Te LinMDPI AGarticlereduced graphene oxideTi<sub>3</sub>C<sub>2</sub>T<sub>x</sub>dopamineuric aciddouble deckBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 462, p 462 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
reduced graphene oxide Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> dopamine uric acid double deck Biotechnology TP248.13-248.65 |
| spellingShingle |
reduced graphene oxide Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> dopamine uric acid double deck Biotechnology TP248.13-248.65 Yangguang Zhu Qichen Tian Xiufen Li Lidong Wu Aimin Yu Guosong Lai Li Fu Qiuping Wei Dan Dai Nan Jiang He Li Chen Ye Cheng-Te Lin A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| description |
Considering the vital physiological functions of dopamine (DA) and uric acid (UA) and their coexistence in the biological matrix, the development of biosensing techniques for their simultaneous and sensitive detection is highly desirable for diagnostic and analytical applications. Therefore, Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO heterostructure with a double-deck layer was fabricated through electrochemical reduction. The rGO was modified on a porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> electrode as the biosensor for the detection of DA and UA simultaneously. Debye length was regulated by the alteration of rGO mass on the surface of the Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> electrode. Debye length decreased with respect to the rGO electrode modified with further rGO mass, indicating that fewer DA molecules were capable of surpassing the equilibrium double layer and reaching the surface of rGO to achieve the voltammetric response of DA. Thus, the proposed Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO sensor presented an excellent performance in detecting DA and UA with a wide linear range of 0.1–100 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M and 1–1000 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M and a low detection limit of 9.5 nM and 0.3 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">μ</mi></semantics></math></inline-formula>M, respectively. Additionally, the proposed Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/rGO electrode displayed good repeatability, selectivity, and proved to be available for real sample analysis. |
| format |
article |
| author |
Yangguang Zhu Qichen Tian Xiufen Li Lidong Wu Aimin Yu Guosong Lai Li Fu Qiuping Wei Dan Dai Nan Jiang He Li Chen Ye Cheng-Te Lin |
| author_facet |
Yangguang Zhu Qichen Tian Xiufen Li Lidong Wu Aimin Yu Guosong Lai Li Fu Qiuping Wei Dan Dai Nan Jiang He Li Chen Ye Cheng-Te Lin |
| author_sort |
Yangguang Zhu |
| title |
A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| title_short |
A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| title_full |
A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| title_fullStr |
A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| title_full_unstemmed |
A Double-Deck Structure of Reduced Graphene Oxide Modified Porous Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Electrode towards Ultrasensitive and Simultaneous Detection of Dopamine and Uric Acid |
| title_sort |
double-deck structure of reduced graphene oxide modified porous ti<sub>3</sub>c<sub>2</sub>t<sub>x</sub> electrode towards ultrasensitive and simultaneous detection of dopamine and uric acid |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/273ebcafb50642cd843af307ac51ced2 |
| work_keys_str_mv |
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1718412826124484608 |