Evolution of kaiA, a key circadian gene of cyanobacteria

Abstract The circadian system of cyanobacteria is built upon a central oscillator consisting of three genes, kaiA, kaiB, and kaiC. The KaiA protein plays a key role in phosphorylation/dephosphorylation cycles of KaiC, which occur over the 24-h period. We conducted a comprehensive evolutionary analys...

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Autores principales:	Volodymyr Dvornyk, Qiming Mei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/273fcb35b8f14e67928063564bf3656f
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spelling	oai:doaj.org-article:273fcb35b8f14e67928063564bf3656f2021-12-02T16:57:26ZEvolution of kaiA, a key circadian gene of cyanobacteria10.1038/s41598-021-89345-72045-2322https://doaj.org/article/273fcb35b8f14e67928063564bf3656f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89345-7https://doaj.org/toc/2045-2322Abstract The circadian system of cyanobacteria is built upon a central oscillator consisting of three genes, kaiA, kaiB, and kaiC. The KaiA protein plays a key role in phosphorylation/dephosphorylation cycles of KaiC, which occur over the 24-h period. We conducted a comprehensive evolutionary analysis of the kaiA genes across cyanobacteria. The results show that, in contrast to the previous reports, kaiA has an ancient origin and is as old as cyanobacteria. The kaiA homologs are present in nearly all analyzed cyanobacteria, except Gloeobacter, and have varying domain architecture. Some Prochlorococcales, which were previously reported to lack the kaiA gene, possess a drastically truncated homolog. The existence of the diverse kaiA homologs suggests significant variation of the circadian mechanism, which was described for the model cyanobacterium, Synechococcus elongatus PCC7942. The major structural modifications in the kaiA genes (duplications, acquisition and loss of domains) have apparently been induced by global environmental changes in the different geological periods.Volodymyr DvornykQiming MeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Volodymyr Dvornyk Qiming Mei Evolution of kaiA, a key circadian gene of cyanobacteria
description	Abstract The circadian system of cyanobacteria is built upon a central oscillator consisting of three genes, kaiA, kaiB, and kaiC. The KaiA protein plays a key role in phosphorylation/dephosphorylation cycles of KaiC, which occur over the 24-h period. We conducted a comprehensive evolutionary analysis of the kaiA genes across cyanobacteria. The results show that, in contrast to the previous reports, kaiA has an ancient origin and is as old as cyanobacteria. The kaiA homologs are present in nearly all analyzed cyanobacteria, except Gloeobacter, and have varying domain architecture. Some Prochlorococcales, which were previously reported to lack the kaiA gene, possess a drastically truncated homolog. The existence of the diverse kaiA homologs suggests significant variation of the circadian mechanism, which was described for the model cyanobacterium, Synechococcus elongatus PCC7942. The major structural modifications in the kaiA genes (duplications, acquisition and loss of domains) have apparently been induced by global environmental changes in the different geological periods.
format	article
author	Volodymyr Dvornyk Qiming Mei
author_facet	Volodymyr Dvornyk Qiming Mei
author_sort	Volodymyr Dvornyk
title	Evolution of kaiA, a key circadian gene of cyanobacteria
title_short	Evolution of kaiA, a key circadian gene of cyanobacteria
title_full	Evolution of kaiA, a key circadian gene of cyanobacteria
title_fullStr	Evolution of kaiA, a key circadian gene of cyanobacteria
title_full_unstemmed	Evolution of kaiA, a key circadian gene of cyanobacteria
title_sort	evolution of kaia, a key circadian gene of cyanobacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/273fcb35b8f14e67928063564bf3656f
work_keys_str_mv	AT volodymyrdvornyk evolutionofkaiaakeycircadiangeneofcyanobacteria AT qimingmei evolutionofkaiaakeycircadiangeneofcyanobacteria
_version_	1718382552569348096

Evolution of kaiA, a key circadian gene of cyanobacteria

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