Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer

<h4>Background</h4> Non-small cell lung cancer (NSCLC) harms human health, but its pathogenesis remains unclear. We wish to provide more molecular therapeutic targets for NSCLC. <h4>Methods</h4> The NSCLC tissue and normal tissue samples were screened for genetic comparison i...

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Autores principales:	Kui Xiao, Yang Wang, Lihua Zhou, Jufen Wang, Yaohui Wang, De Tong, Zhiruo Zhu, Jiehan Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/274275d8c255449da3259d434f2bdb65
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spelling	oai:doaj.org-article:274275d8c255449da3259d434f2bdb652021-11-04T06:49:31ZConstruction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer1932-6203https://doaj.org/article/274275d8c255449da3259d434f2bdb652021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555814/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Non-small cell lung cancer (NSCLC) harms human health, but its pathogenesis remains unclear. We wish to provide more molecular therapeutic targets for NSCLC. <h4>Methods</h4> The NSCLC tissue and normal tissue samples were screened for genetic comparison in the TCGA database. The predicted lncRNA and mRNA in BEAS2B and A549 cells were detected. <h4>Results</h4> Volcano plot displayed differentially expressed lncRNAs and mRNAs in adjacent tissues and NSCLC tissues. The survival curve showed that the lncRNA and mRNA had a significant impact on the patient’s survival. The results of GO term enrichment analysis indicated that mRNA functions were enriched in cell cycle-related pathways. In the ceRNA interaction network, 13 lncRNAs and 20 miRNAs were found to have an interactive relationship. Finally, 3 significantly different lncRNAs (LINC00968, lnc-FAM92A-9 and lnc-PTGFR-1) and 6 mRNAs (CTCFL, KRT5, LY6D, TMEM, GBP6, and TMEM179) with potential therapeutic significance were screened out. And the cell experiment verified our results. <h4>Conclusion</h4> We screened out clinically significant 3 lncRNAs and 6 mRNAs involved in the ceRNA network, which were the key to our future research on the treatment of NSCLC.Kui XiaoYang WangLihua ZhouJufen WangYaohui WangDe TongZhiruo ZhuJiehan JiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kui Xiao Yang Wang Lihua Zhou Jufen Wang Yaohui Wang De Tong Zhiruo Zhu Jiehan Jiang Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
description	<h4>Background</h4> Non-small cell lung cancer (NSCLC) harms human health, but its pathogenesis remains unclear. We wish to provide more molecular therapeutic targets for NSCLC. <h4>Methods</h4> The NSCLC tissue and normal tissue samples were screened for genetic comparison in the TCGA database. The predicted lncRNA and mRNA in BEAS2B and A549 cells were detected. <h4>Results</h4> Volcano plot displayed differentially expressed lncRNAs and mRNAs in adjacent tissues and NSCLC tissues. The survival curve showed that the lncRNA and mRNA had a significant impact on the patient’s survival. The results of GO term enrichment analysis indicated that mRNA functions were enriched in cell cycle-related pathways. In the ceRNA interaction network, 13 lncRNAs and 20 miRNAs were found to have an interactive relationship. Finally, 3 significantly different lncRNAs (LINC00968, lnc-FAM92A-9 and lnc-PTGFR-1) and 6 mRNAs (CTCFL, KRT5, LY6D, TMEM, GBP6, and TMEM179) with potential therapeutic significance were screened out. And the cell experiment verified our results. <h4>Conclusion</h4> We screened out clinically significant 3 lncRNAs and 6 mRNAs involved in the ceRNA network, which were the key to our future research on the treatment of NSCLC.
format	article
author	Kui Xiao Yang Wang Lihua Zhou Jufen Wang Yaohui Wang De Tong Zhiruo Zhu Jiehan Jiang
author_facet	Kui Xiao Yang Wang Lihua Zhou Jufen Wang Yaohui Wang De Tong Zhiruo Zhu Jiehan Jiang
author_sort	Kui Xiao
title	Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
title_short	Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
title_full	Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
title_fullStr	Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
title_full_unstemmed	Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer
title_sort	construction of cerna network to identify the lncrna and mrna related to non-small cell lung cancer
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/274275d8c255449da3259d434f2bdb65
work_keys_str_mv	AT kuixiao constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT yangwang constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT lihuazhou constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT jufenwang constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT yaohuiwang constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT detong constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT zhiruozhu constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer AT jiehanjiang constructionofcernanetworktoidentifythelncrnaandmrnarelatedtononsmallcelllungcancer
_version_	1718445073434148864

Construction of ceRNA network to identify the lncRNA and mRNA related to non-small cell lung cancer

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