Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus

Yaşar Turan,1 Elif Turan2 1Department of Cardiology, Medical School of Bozok University, Yozgat, Turkey; 2Department of Endocrinology and Metabolic Disease, Medical School of Bozok University, Yozgat, TurkeyCorrespondence: Yaşar TuranBozok University, Cardiology, Yozgat 66200, TurkeyTel +90354212705...

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Autores principales:	Turan Y, Turan E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Aortic stiffness carotid intima-media thickness microalbuminuria Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2744e5c2541c429daafc22f3266eb8b4
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spelling	oai:doaj.org-article:2744e5c2541c429daafc22f3266eb8b42021-12-02T03:07:45ZAortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/2744e5c2541c429daafc22f3266eb8b42019-09-01T00:00:00Zhttps://www.dovepress.com/aortic-stiffness-index-and-carotid-intima-media-thickness-are-independ-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yaşar Turan,1 Elif Turan2 1Department of Cardiology, Medical School of Bozok University, Yozgat, Turkey; 2Department of Endocrinology and Metabolic Disease, Medical School of Bozok University, Yozgat, TurkeyCorrespondence: Yaşar TuranBozok University, Cardiology, Yozgat 66200, TurkeyTel +903542127050Fax +903542126201Email yasar044@yahoo.comPurpose: Microalbuminuria is a premature and widely used indicator of diabetic nephropathy and is reported to be related with a higher cardiovascular risk in diabetic patients. We aimed to examine whether the echocardiographic parameters, such as epicardial fat thickness (EFT), carotid intima-media thickness (CIMT) and aortic stiffness index (ASI) are associated with microalbuminuria in patients with diabetes mellitus type 2 (T2DM).Patients and methods: A total of 272 consecutive patients were enrolled and after the exclusion criteria, the data of 180 patients with T2DM were used in this cross-sectional study. Patients were divided into two groups: 82 patients with microalbuminuria and 98 patients without microalbuminuria (normoalbuminuria). The laboratory results and echocardiographic EFT, CIMT and ASI parameters were noted.Results: Compared with the normoalbuminuria group, EFT, CIMT and ASI were significantly higher in the microalbuminuria group (p<0.05 for all). In logistic regression analysis; CIMT (OR: 3.15, p=0.024) and ASI (OR: 4.19, p=0.016) were independently associated with microalbuminuria in patients with T2DM.Conclusion: In addition to CIMT, as a novel finding, ASI which is an indicator for the elastic properties of the aortic root was independently associated with microalbuminuria. CIMT and ASI measurement by echocardiography may be helpful in identifying the accompanying factors in the development of nephropathy.Keywords: aortic stiffness, carotid intima-media thickness, microalbuminuriaTuran YTuran EDove Medical PressarticleAortic stiffnesscarotid intima-media thicknessmicroalbuminuriaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1889-1896 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aortic stiffness carotid intima-media thickness microalbuminuria Specialties of internal medicine RC581-951
spellingShingle	Aortic stiffness carotid intima-media thickness microalbuminuria Specialties of internal medicine RC581-951 Turan Y Turan E Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
description	Yaşar Turan,1 Elif Turan2 1Department of Cardiology, Medical School of Bozok University, Yozgat, Turkey; 2Department of Endocrinology and Metabolic Disease, Medical School of Bozok University, Yozgat, TurkeyCorrespondence: Yaşar TuranBozok University, Cardiology, Yozgat 66200, TurkeyTel +903542127050Fax +903542126201Email yasar044@yahoo.comPurpose: Microalbuminuria is a premature and widely used indicator of diabetic nephropathy and is reported to be related with a higher cardiovascular risk in diabetic patients. We aimed to examine whether the echocardiographic parameters, such as epicardial fat thickness (EFT), carotid intima-media thickness (CIMT) and aortic stiffness index (ASI) are associated with microalbuminuria in patients with diabetes mellitus type 2 (T2DM).Patients and methods: A total of 272 consecutive patients were enrolled and after the exclusion criteria, the data of 180 patients with T2DM were used in this cross-sectional study. Patients were divided into two groups: 82 patients with microalbuminuria and 98 patients without microalbuminuria (normoalbuminuria). The laboratory results and echocardiographic EFT, CIMT and ASI parameters were noted.Results: Compared with the normoalbuminuria group, EFT, CIMT and ASI were significantly higher in the microalbuminuria group (p<0.05 for all). In logistic regression analysis; CIMT (OR: 3.15, p=0.024) and ASI (OR: 4.19, p=0.016) were independently associated with microalbuminuria in patients with T2DM.Conclusion: In addition to CIMT, as a novel finding, ASI which is an indicator for the elastic properties of the aortic root was independently associated with microalbuminuria. CIMT and ASI measurement by echocardiography may be helpful in identifying the accompanying factors in the development of nephropathy.Keywords: aortic stiffness, carotid intima-media thickness, microalbuminuria
format	article
author	Turan Y Turan E
author_facet	Turan Y Turan E
author_sort	Turan Y
title	Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
title_short	Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
title_full	Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
title_fullStr	Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
title_full_unstemmed	Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus
title_sort	aortic stiffness index and carotid intima-media thickness are independently associated with the presence of microalbuminuria in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2744e5c2541c429daafc22f3266eb8b4
work_keys_str_mv	AT turany aorticstiffnessindexandcarotidintimamediathicknessareindependentlyassociatedwiththepresenceofmicroalbuminuriainpatientswithtype2diabetesmellitus AT turane aorticstiffnessindexandcarotidintimamediathicknessareindependentlyassociatedwiththepresenceofmicroalbuminuriainpatientswithtype2diabetesmellitus
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Aortic Stiffness Index And Carotid Intima-Media Thickness Are Independently Associated With The Presence Of Microalbuminuria In Patients With Type 2 Diabetes Mellitus

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