Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome
Xin Zheng,1,2,* Yun Chen,3,* Danyan Ma,4 Mulin Zhang,1,2 Yinxiang Huang,1,2 Meifeng Tong,1,2 Bing Yan,1,2 Shaowei Lin,5 Xiaohong Yan,6 Changqin Liu1– 3 1Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China; 2Fujian Province Key Laborat...
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Dove Medical Press
2021
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oai:doaj.org-article:2747fb606b1b4a238b4dab39eeed95112021-12-02T15:24:16ZCorrelation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome1178-7007https://doaj.org/article/2747fb606b1b4a238b4dab39eeed95112021-01-01T00:00:00Zhttps://www.dovepress.com/correlation-between-daily-energy-intake-from-fat-with-insulin-resistan-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xin Zheng,1,2,* Yun Chen,3,* Danyan Ma,4 Mulin Zhang,1,2 Yinxiang Huang,1,2 Meifeng Tong,1,2 Bing Yan,1,2 Shaowei Lin,5 Xiaohong Yan,6 Changqin Liu1– 3 1Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China; 2Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China; 3The School of Clinical Medicine, Fujian Medical University, Fuzhou, China; 4School of Medicine, Xiamen University, Xiamen, China; 5Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China; 6Reproductive Medicine Center, The First Affiliated Hospital of Xiamen University, Xiamen, China*These authors contributed equally to this workCorrespondence: Changqin LiuDepartment of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaTel +86-592-2137796Fax +86-592-2137189Email liuchangqin@xmu.edu.cnXiaohong YanReproductive Medicine Center, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaTel +86-592-2662318Fax +86-592-2662318Email xmyxh1224@sina.comObjective: The aim of the present study was to investigate the possible correlation between the percentage of daily energy intake from fat (PEF) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).Methods: In this cross-sectional study, a total of 186 females with PCOS were screened. Daily dietary intake data were collected by a trained nutritionist using the 24-h dietary recall method over three consecutive days. A total of 111 subjects who had complete data were divided into two groups based on the percentage of daily energy intake from fat (PEF): the normal PEF (NPEF) group (PEF < 30%) and the high PEF (HPEF) group (PEF ≥ 30%). Pearson’s correlation analysis and stepwise multivariate linear regression analysis were used to analyze the correlation of PEF with homeostasis model assessment of insulin resistance (HOMA-IR).Results: The total prevalence rate of overweight/obesity was 80.2%. There were significant differences in waist circumference (WC), body mass index (BMI), fasting insulin, and HOMA-IR (P < 0.001) among the normal weight, the overweight, and the obese groups, but no significant differences were observed in total energy and dietary macronutrients intake in the three groups. The daily intake of fat and protein, fasting insulin, and HOMA-IR in the NPEF group were significantly higher than those in the HPEF group. Pearson’s correlation analysis showed PEF in PCOS women was negatively correlated with BMI (r= − 0.189, p=0.047) and HOMA-IR (log-transformed) (r= − 0.217, p=0.022). Further, stepwise multivariate linear regression analysis showed PEF was negatively correlated with HOMA-IR (p< 0.05).Conclusion: The percentage of daily energy intake from fat is negatively correlated with IR in women with PCOS.Keywords: the percentage of daily energy intake from fat, polycystic ovary syndrome, insulin resistance, daily dietary intake, obesityZheng XChen YMa DZhang MHuang YTong MYan BLin SYan XLiu CDove Medical Pressarticlethe percentage of daily energy intake from fatpolycystic ovary syndromeinsulin resistancedaily dietary intakeobesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 295-303 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
the percentage of daily energy intake from fat polycystic ovary syndrome insulin resistance daily dietary intake obesity Specialties of internal medicine RC581-951 |
| spellingShingle |
the percentage of daily energy intake from fat polycystic ovary syndrome insulin resistance daily dietary intake obesity Specialties of internal medicine RC581-951 Zheng X Chen Y Ma D Zhang M Huang Y Tong M Yan B Lin S Yan X Liu C Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| description |
Xin Zheng,1,2,* Yun Chen,3,* Danyan Ma,4 Mulin Zhang,1,2 Yinxiang Huang,1,2 Meifeng Tong,1,2 Bing Yan,1,2 Shaowei Lin,5 Xiaohong Yan,6 Changqin Liu1– 3 1Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China; 2Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China; 3The School of Clinical Medicine, Fujian Medical University, Fuzhou, China; 4School of Medicine, Xiamen University, Xiamen, China; 5Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China; 6Reproductive Medicine Center, The First Affiliated Hospital of Xiamen University, Xiamen, China*These authors contributed equally to this workCorrespondence: Changqin LiuDepartment of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaTel +86-592-2137796Fax +86-592-2137189Email liuchangqin@xmu.edu.cnXiaohong YanReproductive Medicine Center, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaTel +86-592-2662318Fax +86-592-2662318Email xmyxh1224@sina.comObjective: The aim of the present study was to investigate the possible correlation between the percentage of daily energy intake from fat (PEF) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).Methods: In this cross-sectional study, a total of 186 females with PCOS were screened. Daily dietary intake data were collected by a trained nutritionist using the 24-h dietary recall method over three consecutive days. A total of 111 subjects who had complete data were divided into two groups based on the percentage of daily energy intake from fat (PEF): the normal PEF (NPEF) group (PEF < 30%) and the high PEF (HPEF) group (PEF ≥ 30%). Pearson’s correlation analysis and stepwise multivariate linear regression analysis were used to analyze the correlation of PEF with homeostasis model assessment of insulin resistance (HOMA-IR).Results: The total prevalence rate of overweight/obesity was 80.2%. There were significant differences in waist circumference (WC), body mass index (BMI), fasting insulin, and HOMA-IR (P < 0.001) among the normal weight, the overweight, and the obese groups, but no significant differences were observed in total energy and dietary macronutrients intake in the three groups. The daily intake of fat and protein, fasting insulin, and HOMA-IR in the NPEF group were significantly higher than those in the HPEF group. Pearson’s correlation analysis showed PEF in PCOS women was negatively correlated with BMI (r= − 0.189, p=0.047) and HOMA-IR (log-transformed) (r= − 0.217, p=0.022). Further, stepwise multivariate linear regression analysis showed PEF was negatively correlated with HOMA-IR (p< 0.05).Conclusion: The percentage of daily energy intake from fat is negatively correlated with IR in women with PCOS.Keywords: the percentage of daily energy intake from fat, polycystic ovary syndrome, insulin resistance, daily dietary intake, obesity |
| format |
article |
| author |
Zheng X Chen Y Ma D Zhang M Huang Y Tong M Yan B Lin S Yan X Liu C |
| author_facet |
Zheng X Chen Y Ma D Zhang M Huang Y Tong M Yan B Lin S Yan X Liu C |
| author_sort |
Zheng X |
| title |
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| title_short |
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| title_full |
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| title_fullStr |
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| title_full_unstemmed |
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome |
| title_sort |
correlation between daily energy intake from fat with insulin resistance in patients with polycystic ovary syndrome |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/2747fb606b1b4a238b4dab39eeed9511 |
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