Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative

Bisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear. We found that bisphosphonate use did not increase sclerosis of subchondral bone in established KOA, perhaps resolving some concerns...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mingyang Li, Yong Nie, Yi Zeng, Yuangang Wu, Yuan Liu, Limin Wu, Jiawen Xu, Bin Shen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bisphosphonate subchondral bone morphometry BVF Tb.N Tb.Sp Tb.Th Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/274ec40d9b854b16816de8dd9c816136
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:274ec40d9b854b16816de8dd9c816136
record_format	dspace
spelling	oai:doaj.org-article:274ec40d9b854b16816de8dd9c8161362021-11-22T10:27:55ZDoes Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative2296-858X10.3389/fmed.2021.781219https://doaj.org/article/274ec40d9b854b16816de8dd9c8161362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.781219/fullhttps://doaj.org/toc/2296-858XBisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear. We found that bisphosphonate use did not increase sclerosis of subchondral bone in established KOA, perhaps resolving some concerns about bisphosphonate in patients with KOA.Introduction: Most studies have focused on the protective effect of bisphosphonate on early knee osteoarthritis (KOA) through its anti-resorption mechanism in osteoclasts. However, late KOA has a decreased rate of resorption, which is the opposite of early KOA. The risk of subchondral bone sclerosis in late KOA after using bisphosphonate has not been investigated using morphometry.Methods: Forty-five patients who had ever used bisphosphonate (or 33 patients with current use) were matched with controls through propensity matching methods, including age, body mass index (BMI), sex, health status (12-Item Short Form Survey physical health score), physical activity level (Physical Activity Scale for the Elderly score), vitamin D use, and calcium use. At the baseline and 12-month (or 18-month) follow-up, bone mineral density (BMD) of the tibia and hip was measured by dual-energy X-ray absorptiometry (DXA), and medial tibial subchondral bone morphometry: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) were calculated based on 3-T trabecular MRI. Data were obtained from the Bone Ancillary Study in the Osteoarthritis Initiative (OAI) project.Results: The yearly percentage change in hip BMD of the current bisphosphonate-use group was significantly greater than that of the non-bisphosphonate-use group (0.7% vs. −1%, P = 0.02). The other outcomes (BV/TV, Tb.N, Tb.Sp, Tb.Th, tibia medial BMD, and tibia lateral BMD) between the two groups presented no significant difference. The non-bisphosphonate-use group experienced a significant increase in Tb.Th [2%, 95% CI = (1%, 4%), P = 0.01], while the bisphosphonate-use group presented no significant change [1%, 95% CI = (−2%, 4%), P = 0.54].Conclusions: Bisphosphonate use did not increase sclerosis of subchondral bone in established KOA. Bisphosphonate might have a stage-dependent effect on subchondral bone in KOA initiation and progression.Mingyang LiYong NieYi ZengYuangang WuYuan LiuLimin WuJiawen XuBin ShenFrontiers Media S.A.articlebisphosphonatesubchondral bone morphometryBVFTb.NTb.SpTb.ThMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphosphonate subchondral bone morphometry BVF Tb.N Tb.Sp Tb.Th Medicine (General) R5-920
spellingShingle	bisphosphonate subchondral bone morphometry BVF Tb.N Tb.Sp Tb.Th Medicine (General) R5-920 Mingyang Li Yong Nie Yi Zeng Yuangang Wu Yuan Liu Limin Wu Jiawen Xu Bin Shen Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
description	Bisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear. We found that bisphosphonate use did not increase sclerosis of subchondral bone in established KOA, perhaps resolving some concerns about bisphosphonate in patients with KOA.Introduction: Most studies have focused on the protective effect of bisphosphonate on early knee osteoarthritis (KOA) through its anti-resorption mechanism in osteoclasts. However, late KOA has a decreased rate of resorption, which is the opposite of early KOA. The risk of subchondral bone sclerosis in late KOA after using bisphosphonate has not been investigated using morphometry.Methods: Forty-five patients who had ever used bisphosphonate (or 33 patients with current use) were matched with controls through propensity matching methods, including age, body mass index (BMI), sex, health status (12-Item Short Form Survey physical health score), physical activity level (Physical Activity Scale for the Elderly score), vitamin D use, and calcium use. At the baseline and 12-month (or 18-month) follow-up, bone mineral density (BMD) of the tibia and hip was measured by dual-energy X-ray absorptiometry (DXA), and medial tibial subchondral bone morphometry: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) were calculated based on 3-T trabecular MRI. Data were obtained from the Bone Ancillary Study in the Osteoarthritis Initiative (OAI) project.Results: The yearly percentage change in hip BMD of the current bisphosphonate-use group was significantly greater than that of the non-bisphosphonate-use group (0.7% vs. −1%, P = 0.02). The other outcomes (BV/TV, Tb.N, Tb.Sp, Tb.Th, tibia medial BMD, and tibia lateral BMD) between the two groups presented no significant difference. The non-bisphosphonate-use group experienced a significant increase in Tb.Th [2%, 95% CI = (1%, 4%), P = 0.01], while the bisphosphonate-use group presented no significant change [1%, 95% CI = (−2%, 4%), P = 0.54].Conclusions: Bisphosphonate use did not increase sclerosis of subchondral bone in established KOA. Bisphosphonate might have a stage-dependent effect on subchondral bone in KOA initiation and progression.
format	article
author	Mingyang Li Yong Nie Yi Zeng Yuangang Wu Yuan Liu Limin Wu Jiawen Xu Bin Shen
author_facet	Mingyang Li Yong Nie Yi Zeng Yuangang Wu Yuan Liu Limin Wu Jiawen Xu Bin Shen
author_sort	Mingyang Li
title	Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
title_short	Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
title_full	Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
title_fullStr	Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
title_full_unstemmed	Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
title_sort	does bisphosphonate increase the sclerosis of tibial subchondral bone in the progression of knee osteoarthritis—a propensity score matching cohort study based on osteoarthritis initiative
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/274ec40d9b854b16816de8dd9c816136
work_keys_str_mv	AT mingyangli doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT yongnie doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT yizeng doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT yuangangwu doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT yuanliu doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT liminwu doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT jiawenxu doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative AT binshen doesbisphosphonateincreasethesclerosisoftibialsubchondralboneintheprogressionofkneeosteoarthritisapropensityscorematchingcohortstudybasedonosteoarthritisinitiative
_version_	1718417722033831936

Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative

Ejemplares similares