Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different Candida Species

This study investigated the effect of CAPE on planktonic growth, biofilm-forming abilities, mature biofilms, and cell death of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis strains. Our results showed a strain...

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Autores principales:	Ibrahim Alfarrayeh, Edit Pollák, Árpád Czéh, András Vida, Sourav Das, Gábor Papp
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CAPE <i>Candida</i> antifungal biofilm apoptosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/274ef5b48c034295abc7884f3f629776
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spelling	oai:doaj.org-article:274ef5b48c034295abc7884f3f6297762021-11-25T16:23:34ZAntifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species10.3390/antibiotics101113592079-6382https://doaj.org/article/274ef5b48c034295abc7884f3f6297762021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1359https://doaj.org/toc/2079-6382This study investigated the effect of CAPE on planktonic growth, biofilm-forming abilities, mature biofilms, and cell death of <i>C. albicans</i>, <i>C. tropicalis</i>, <i>C. glabrata</i>, and <i>C. parapsilosis</i> strains. Our results showed a strain- and dose-dependent effect of CAPE on <i>Candida</i>, and the MIC values were between 12.5 and 100 µg/mL. Similarly, the MBIC values of CAPE ranging between 50 and 100 µg/mL highlighted the inhibition of the biofilm-forming abilities in a dose-dependent manner, as well. However, CAPE showed a weak to moderate biofilm eradication ability (19-49%) on different <i>Candida</i> strains mature biofilms. Both caspase-dependent and caspase-independent apoptosis after CAPE treatment were observed in certain tested <i>Candida</i> strains. Our study has displayed typical apoptotic hallmarks of CAPE-induced chromatin margination, nuclear blebs, nuclear condensation, plasma membrane detachment, enlarged lysosomes, cytoplasm fragmentation, cell wall distortion, whole-cell shrinkage, and necrosis. In conclusion, CAPE has a concentration and strain-dependent inhibitory activity on viability, biofilm formation ability, and cell death response in the different <i>Candida</i> species.Ibrahim AlfarrayehEdit PollákÁrpád CzéhAndrás VidaSourav DasGábor PappMDPI AGarticleCAPE<i>Candida</i>antifungalbiofilmapoptosisTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1359, p 1359 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CAPE <i>Candida</i> antifungal biofilm apoptosis Therapeutics. Pharmacology RM1-950
spellingShingle	CAPE <i>Candida</i> antifungal biofilm apoptosis Therapeutics. Pharmacology RM1-950 Ibrahim Alfarrayeh Edit Pollák Árpád Czéh András Vida Sourav Das Gábor Papp Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
description	This study investigated the effect of CAPE on planktonic growth, biofilm-forming abilities, mature biofilms, and cell death of <i>C. albicans</i>, <i>C. tropicalis</i>, <i>C. glabrata</i>, and <i>C. parapsilosis</i> strains. Our results showed a strain- and dose-dependent effect of CAPE on <i>Candida</i>, and the MIC values were between 12.5 and 100 µg/mL. Similarly, the MBIC values of CAPE ranging between 50 and 100 µg/mL highlighted the inhibition of the biofilm-forming abilities in a dose-dependent manner, as well. However, CAPE showed a weak to moderate biofilm eradication ability (19-49%) on different <i>Candida</i> strains mature biofilms. Both caspase-dependent and caspase-independent apoptosis after CAPE treatment were observed in certain tested <i>Candida</i> strains. Our study has displayed typical apoptotic hallmarks of CAPE-induced chromatin margination, nuclear blebs, nuclear condensation, plasma membrane detachment, enlarged lysosomes, cytoplasm fragmentation, cell wall distortion, whole-cell shrinkage, and necrosis. In conclusion, CAPE has a concentration and strain-dependent inhibitory activity on viability, biofilm formation ability, and cell death response in the different <i>Candida</i> species.
format	article
author	Ibrahim Alfarrayeh Edit Pollák Árpád Czéh András Vida Sourav Das Gábor Papp
author_facet	Ibrahim Alfarrayeh Edit Pollák Árpád Czéh András Vida Sourav Das Gábor Papp
author_sort	Ibrahim Alfarrayeh
title	Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
title_short	Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
title_full	Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
title_fullStr	Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
title_full_unstemmed	Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species
title_sort	antifungal and anti-biofilm effects of caffeic acid phenethyl ester on different <i>candida</i> species
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/274ef5b48c034295abc7884f3f629776
work_keys_str_mv	AT ibrahimalfarrayeh antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies AT editpollak antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies AT arpadczeh antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies AT andrasvida antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies AT souravdas antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies AT gaborpapp antifungalandantibiofilmeffectsofcaffeicacidphenethylesterondifferenticandidaispecies
_version_	1718413188656005120

Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different <i>Candida</i> Species

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