Ndufa6 regulates adipogenic differentiation via Scd1

Background Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet t...

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Autores principales:	Jingwei Zhang, Wei Wang, Ninghan Feng, Xuan Jiang, Shenglong Zhu, Yong Q Chen
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	obesity adipogenic differentiation ndufa6 scd Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/27511d5f6f60430598d7247d000273d7
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spelling	oai:doaj.org-article:27511d5f6f60430598d7247d000273d72021-11-26T11:19:49ZNdufa6 regulates adipogenic differentiation via Scd12162-39452162-397X10.1080/21623945.2021.2007590https://doaj.org/article/27511d5f6f60430598d7247d000273d72021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21623945.2021.2007590https://doaj.org/toc/2162-3945https://doaj.org/toc/2162-397XBackground Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Methods Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. Results In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Conclusions Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity.Jingwei ZhangWei WangNinghan FengXuan JiangShenglong ZhuYong Q ChenTaylor & Francis Grouparticleobesityadipogenic differentiationndufa6scdDiseases of the endocrine glands. Clinical endocrinologyRC648-665CytologyQH573-671PhysiologyQP1-981ENAdipocyte, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity adipogenic differentiation ndufa6 scd Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
spellingShingle	obesity adipogenic differentiation ndufa6 scd Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981 Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen Ndufa6 regulates adipogenic differentiation via Scd1
description	Background Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Methods Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. Results In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Conclusions Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity.
format	article
author	Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen
author_facet	Jingwei Zhang Wei Wang Ninghan Feng Xuan Jiang Shenglong Zhu Yong Q Chen
author_sort	Jingwei Zhang
title	Ndufa6 regulates adipogenic differentiation via Scd1
title_short	Ndufa6 regulates adipogenic differentiation via Scd1
title_full	Ndufa6 regulates adipogenic differentiation via Scd1
title_fullStr	Ndufa6 regulates adipogenic differentiation via Scd1
title_full_unstemmed	Ndufa6 regulates adipogenic differentiation via Scd1
title_sort	ndufa6 regulates adipogenic differentiation via scd1
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/27511d5f6f60430598d7247d000273d7
work_keys_str_mv	AT jingweizhang ndufa6regulatesadipogenicdifferentiationviascd1 AT weiwang ndufa6regulatesadipogenicdifferentiationviascd1 AT ninghanfeng ndufa6regulatesadipogenicdifferentiationviascd1 AT xuanjiang ndufa6regulatesadipogenicdifferentiationviascd1 AT shenglongzhu ndufa6regulatesadipogenicdifferentiationviascd1 AT yongqchen ndufa6regulatesadipogenicdifferentiationviascd1
_version_	1718409456157458432

Ndufa6 regulates adipogenic differentiation via Scd1

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